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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: ozorhan u. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Roles of adiponectin and leptin signaling-related microRNAs in the preventive effects of calorie restriction in mammary tumor development.
Dogan S, Cicekdal MB, Ozorhan U, Karabiyik G, Kazan BT, Ekici ID, Yilmaz B, Demirel PB, Coban I, Tuysuz EC, Kuskucu A, Bayrak OF, Cleary MP, Tuna BG. Dogan S, et al. Among authors: ozorhan u. Appl Physiol Nutr Metab. 2021 Aug;46(8):866-876. doi: 10.1139/apnm-2020-1000. Epub 2021 Jan 25. Appl Physiol Nutr Metab. 2021. PMID: 33493087
Effects of two types of energy restriction on methylation levels of adiponectin receptor 1 and leptin receptor overlapping transcript in a mouse mammary tumour virus-transforming growth factor-α breast cancer mouse model.
Cicekdal MB, Kazan BT, Tuna BG, Ozorhan U, Ekici ID, Zhu F, Suakar O, Kuskucu A, Bayrak OF, Arcaro K, Cleary MP, Atasayan O, Yilmaz B, Dogan S. Cicekdal MB, et al. Among authors: ozorhan u. Br J Nutr. 2021 Jan 14;125(1):1-9. doi: 10.1017/S0007114519002757. Epub 2019 Nov 5. Br J Nutr. 2021. PMID: 31685042
Effects of Two Types of Calorie Restriction on Methylation Levels of Adiponectin Receptor 1 (AdipoR1) and Leptin Receptor Overlapping Transcript (Leprot) in a MMTV-TGF-α Breast Cancer Mouse Model.
Cicekdal MB, Kazan BT, Tuna BG, Ozorhan U, Ekici ID, Zhu F, Suakar O, Kuskucu A, Bayrak OF, Arcaro K, Cleary MP, Dogan S. Cicekdal MB, et al. Among authors: ozorhan u. Br J Nutr. 2020 May 14;123(9):1079. doi: 10.1017/S0007114520000471. Br J Nutr. 2020. PMID: 32616101 No abstract available.
Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory.
Hernandez Torres LD, Rezende F, Peschke E, Will O, Hövener JB, Spiecker F, Özorhan Ü, Lampe J, Stölting I, Aherrahrou Z, Künne C, Kusche-Vihrog K, Matschl U, Hille S, Brandes RP, Schwaninger M, Müller OJ, Raasch W. Hernandez Torres LD, et al. Among authors: ozorhan u. Front Endocrinol (Lausanne). 2024 Feb 26;15:1338458. doi: 10.3389/fendo.2024.1338458. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38469142 Free PMC article.