Öster L - Search Results

1

Successful generation of structural information for fragment-based drug discovery.

Öster L, Tapani S, Xue Y, Käck H. Öster L, et al. Drug Discov Today. 2015 Sep;20(9):1104-11. doi: 10.1016/j.drudis.2015.04.005. Epub 2015 Apr 28. Drug Discov Today. 2015. PMID: 25931264 Review.

2

FAM3B PANDER and FAM3C ILEI represent a distinct class of signaling molecules with a non-cytokine-like fold.

Johansson P, Bernström J, Gorman T, Oster L, Bäckström S, Schweikart F, Xu B, Xue Y, Schiavone LH. Johansson P, et al. Among authors: oster l. Structure. 2013 Feb 5;21(2):306-13. doi: 10.1016/j.str.2012.12.009. Epub 2013 Jan 17. Structure. 2013. PMID: 23333428 Free article.

3

Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.

Chen H, Knerr L, Åkerud T, Hallberg K, Öster L, Rohman M, Österlund K, Beisel HG, Olsson T, Brengdhal J, Sandmark J, Bodin C. Chen H, et al. Among authors: oster l. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5251-5. doi: 10.1016/j.bmcl.2014.09.058. Epub 2014 Sep 30. Bioorg Med Chem Lett. 2014. PMID: 25316315

4

Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.

Fjellström O, Akkaya S, Beisel HG, Eriksson PO, Erixon K, Gustafsson D, Jurva U, Kang D, Karis D, Knecht W, Nerme V, Nilsson I, Olsson T, Redzic A, Roth R, Sandmark J, Tigerström A, Öster L. Fjellström O, et al. Among authors: oster l. PLoS One. 2015 Jan 28;10(1):e0113705. doi: 10.1371/journal.pone.0113705. eCollection 2015. PLoS One. 2015. PMID: 25629509 Free PMC article.

5

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.

Hennessy EJ, Oza V, Adam A, Byth K, Castriotta L, Grewal G, Hamilton GA, Kamhi VM, Lewis P, Li D, Lyne P, Öster L, Rooney MT, Saeh JC, Sha L, Su Q, Wen S, Xue Y, Yang B. Hennessy EJ, et al. Among authors: oster l. J Med Chem. 2015 Sep 10;58(17):7057-75. doi: 10.1021/acs.jmedchem.5b01078. Epub 2015 Aug 26. J Med Chem. 2015. PMID: 26291341

6

Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration.

Xue Y, Olsson T, Johansson CA, Öster L, Beisel HG, Rohman M, Karis D, Bäckström S. Xue Y, et al. Among authors: oster l. ChemMedChem. 2016 Mar 4;11(5):497-508. doi: 10.1002/cmdc.201500575. Epub 2016 Feb 4. ChemMedChem. 2016. PMID: 26845235

7

Fragment-Based Discovery of Novel Allosteric MEK1 Binders.

Di Fruscia P, Edfeldt F, Shamovsky I, Collie GW, Aagaard A, Barlind L, Börjesson U, Hansson EL, Lewis RJ, Nilsson MK, Öster L, Pemberton J, Ripa L, Storer RI, Käck H. Di Fruscia P, et al. Among authors: oster l. ACS Med Chem Lett. 2021 Jan 27;12(2):302-308. doi: 10.1021/acsmedchemlett.0c00563. eCollection 2021 Feb 11. ACS Med Chem Lett. 2021. PMID: 33603979 Free PMC article.

8

Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors.

Schiesser S, Hajek P, Pople HE, Käck H, Öster L, Cox RJ. Schiesser S, et al. Among authors: oster l. Eur J Med Chem. 2022 Jan 5;227:113925. doi: 10.1016/j.ejmech.2021.113925. Epub 2021 Oct 21. Eur J Med Chem. 2022. PMID: 34742013

9

The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity.

Öster L, Castaldo M, de Vries E, Edfeldt F, Pemberton N, Gordon E, Cederblad L, Käck H. Öster L, et al. J Biol Chem. 2024 Mar 18;300(5):107201. doi: 10.1016/j.jbc.2024.107201. Online ahead of print. J Biol Chem. 2024. PMID: 38508313 Free PMC article.

10

Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa.

Buchanan MS, Carroll AR, Wessling D, Jobling M, Avery VM, Davis RA, Feng Y, Xue Y, Oster L, Fex T, Deinum J, Hooper JN, Quinn RJ. Buchanan MS, et al. Among authors: oster l. J Med Chem. 2008 Jun 26;51(12):3583-7. doi: 10.1021/jm800314b. J Med Chem. 2008. PMID: 18510371

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