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3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies.
Couto M, Sánchez C, Dávila B, Machín V, Varela J, Álvarez G, Cabrera M, Celano L, Aguirre-López B, Cabrera N, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Cerecetto H, González M. Couto M, et al. Among authors: alvarez g. Molecules. 2015 Aug 12;20(8):14595-610. doi: 10.3390/molecules200814595. Molecules. 2015. PMID: 26274947 Free PMC article.
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.
Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A. Alvarez G, et al. Eur J Med Chem. 2010 Dec;45(12):5767-72. doi: 10.1016/j.ejmech.2010.09.034. Epub 2010 Sep 19. Eur J Med Chem. 2010. PMID: 20889239
1,2,4-thiadiazol-5(4H)-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition.
Alvarez G, Aguirre-López B, Cabrera N, Marins EB, Tinoco L, Batthyány CI, de Gómez-Puyou MT, Puyou AG, Pérez-Montfort R, Cerecetto H, González M. Alvarez G, et al. J Enzyme Inhib Med Chem. 2013 Oct;28(5):981-9. doi: 10.3109/14756366.2012.700928. Epub 2012 Jul 18. J Enzyme Inhib Med Chem. 2013. PMID: 22803666
Evaluating 5-nitrofurans as trypanocidal agents.
Bot C, Hall BS, Alvarez G, Di Maio R, González M, Cerecetto H, Wilkinson SR. Bot C, et al. Among authors: alvarez g. Antimicrob Agents Chemother. 2013 Apr;57(4):1638-47. doi: 10.1128/AAC.02046-12. Epub 2013 Jan 18. Antimicrob Agents Chemother. 2013. PMID: 23335745 Free PMC article.
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.
Alvarez G, Martínez J, Aguirre-López B, Cabrera N, Pérez-Díaz L, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Garat B, Merlino A, González M, Cerecetto H. Alvarez G, et al. J Enzyme Inhib Med Chem. 2014 Apr;29(2):198-204. doi: 10.3109/14756366.2013.765415. Epub 2013 Feb 13. J Enzyme Inhib Med Chem. 2014. PMID: 23406473
Trypanosoma cruzi chemical proteomics using immobilized benznidazole.
Trochine A, Alvarez G, Corre S, Faral-Tello P, Durán R, Batthyany CI, Cerecetto H, González M, Robello C. Trochine A, et al. Among authors: alvarez g. Exp Parasitol. 2014 May;140:33-8. doi: 10.1016/j.exppara.2014.03.013. Epub 2014 Mar 13. Exp Parasitol. 2014. PMID: 24632192
Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease.
Álvarez G, Varela J, Cruces E, Fernández M, Gabay M, Leal SM, Escobar P, Sanabria L, Serna E, Torres S, Figueredo Thiel SJ, Yaluff G, Vera de Bilbao NI, Cerecetto H, González M. Álvarez G, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1398-404. doi: 10.1128/AAC.03814-14. Epub 2014 Dec 15. Antimicrob Agents Chemother. 2015. PMID: 25512408 Free PMC article.
809 results