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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2010 2
2011 9
2012 10
2013 6
2014 9
2015 7
2016 10
2017 2
2018 1
2024 0

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48 results

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Page 1
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team. Schreiber SL, et al. Cell. 2015 Jun 4;161(6):1252-65. doi: 10.1016/j.cell.2015.05.023. Cell. 2015. PMID: 26046436 Free PMC article. Review.
5-Methyl-7,8,9,10-tetra-hydro-cyclo-hepta-[b]indol-6(5H)-one.
Archana R, Yamuna E, Rajendra Prasad KJ, Thiruvalluvar A, Butcher RJ. Archana R, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1325. doi: 10.1107/S1600536811016229. Epub 2011 May 7. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21754722 Free PMC article.
A substrate-driven allosteric switch that enhances PDI catalytic activity.
Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A, Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R. Bekendam RH, et al. Nat Commun. 2016 Aug 30;7:12579. doi: 10.1038/ncomms12579. Nat Commun. 2016. PMID: 27573496 Free PMC article.
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.
Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V, Narayan R, Subramanian A, Winckler W, Golub TR, Carpenter AE, Shamji AF, Schreiber SL, Clemons PA. Wawer MJ, et al. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):10911-6. doi: 10.1073/pnas.1410933111. Epub 2014 Jul 14. Proc Natl Acad Sci U S A. 2014. PMID: 25024206 Free PMC article.
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.
Huang F, Goyal N, Sullivan K, Hanamshet K, Patel M, Mazina OM, Wang CX, An WF, Spoonamore J, Metkar S, Emmitte KA, Cocklin S, Skorski T, Mazin AV. Huang F, et al. Nucleic Acids Res. 2016 May 19;44(9):4189-99. doi: 10.1093/nar/gkw087. Epub 2016 Feb 11. Nucleic Acids Res. 2016. PMID: 26873923 Free PMC article.
Identification of a selective small molecule inhibitor of breast cancer stem cells.
Germain AR, Carmody LC, Morgan B, Fernandez C, Forbeck E, Lewis TA, Nag PP, Ting A, VerPlank L, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B. Germain AR, et al. Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4. doi: 10.1016/j.bmcl.2012.01.035. Epub 2012 Jan 25. Bioorg Med Chem Lett. 2012. PMID: 22503247
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Sharabi K, Lin H, Tavares CDJ, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Sharabi K, et al. Cell. 2017 Mar 23;169(1):148-160.e15. doi: 10.1016/j.cell.2017.03.001. Cell. 2017. PMID: 28340340 Free PMC article.
48 results