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Macrocyclic inhibitors of hsp90.
Johnson VA, Singh EK, Nazarova LA, Alexander LD, McAlpine SR. Johnson VA, et al. Curr Top Med Chem. 2010;10(14):1380-402. doi: 10.2174/156802610792232088. Curr Top Med Chem. 2010. PMID: 20536417 Free PMC article. Review.
Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives.
Sellers RP, Alexander LD, Johnson VA, Lin CC, Savage J, Corral R, Moss J, Slugocki TS, Singh EK, Davis MR, Ravula S, Spicer JE, Oelrich JL, Thornquist A, Pan CM, McAlpine SR. Sellers RP, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6822-56. doi: 10.1016/j.bmc.2010.07.042. Epub 2010 Jul 22. Bioorg Med Chem. 2010. PMID: 20708938 Free PMC article.
An Hsp90 modulator that exhibits a unique mechanistic profile.
Ramsey DM, McConnell JR, Alexander LD, Tanaka KW, Vera CM, McAlpine SR. Ramsey DM, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3287-90. doi: 10.1016/j.bmcl.2012.03.012. Epub 2012 Mar 11. Bioorg Med Chem Lett. 2012. PMID: 22480433 Free PMC article.