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Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug.
Antimicrob Agents Chemother. 2016.
PMID: 27270277
Free PMC article.
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ.
Sonoiki E, et al.
Nat Commun. 2017 Mar 6;8:14574. doi: 10.1038/ncomms14574.
Nat Commun. 2017.
PMID: 28262680
Free PMC article.
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Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y.
Zhang YK, et al.
J Med Chem. 2015 Jul 9;58(13):5344-54. doi: 10.1021/acs.jmedchem.5b00678. Epub 2015 Jun 23.
J Med Chem. 2015.
PMID: 26067904
Free PMC article.
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Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ.
Sindhe KMV, et al.
mBio. 2020 Jan 28;11(1):e02640-19. doi: 10.1128/mBio.02640-19.
mBio. 2020.
PMID: 31992618
Free PMC article.
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