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Modeling the complex pathology of Alzheimer's disease in Drosophila.
Exp Neurol. 2015 Dec;274(Pt A):58-71. doi: 10.1016/j.expneurol.2015.05.013. Epub 2015 May 27.
Exp Neurol. 2015.
PMID: 26024860
Free PMC article.
Review.
Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity.
Fernandez-Funez P, Sanchez-Garcia J, Rincon-Limas DE.
Fernandez-Funez P, et al.
Curr Opin Genet Dev. 2017 Jun;44:141-148. doi: 10.1016/j.gde.2017.03.013. Epub 2017 Apr 14.
Curr Opin Genet Dev. 2017.
PMID: 28415023
Free PMC article.
Review.
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Y225A induces long-range conformational changes in human prion protein that are protective in Drosophila.
Myers RR, John A, Zhang W, Zou WQ, Cembran A, Fernandez-Funez P.
Myers RR, et al.
J Biol Chem. 2023 Jul;299(7):104881. doi: 10.1016/j.jbc.2023.104881. Epub 2023 Jun 2.
J Biol Chem. 2023.
PMID: 37269948
Free PMC article.
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New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein.
Myers RR, Sanchez-Garcia J, Leving DC, Melvin RG, Fernandez-Funez P.
Myers RR, et al.
Dis Model Mech. 2022 Apr 1;15(4):dmm049184. doi: 10.1242/dmm.049184. Epub 2022 May 3.
Dis Model Mech. 2022.
PMID: 35142350
Free PMC article.
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D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals.
Sanchez-Garcia J, Fernandez-Funez P.
Sanchez-Garcia J, et al.
Neurobiol Dis. 2018 Nov;119:1-12. doi: 10.1016/j.nbd.2018.07.011. Epub 2018 Jul 24.
Neurobiol Dis. 2018.
PMID: 30010001
Free PMC article.
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A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.
Sanchez-Garcia J, Jensen K, Zhang Y, Rincon-Limas DE, Fernandez-Funez P.
Sanchez-Garcia J, et al.
Neurobiol Dis. 2016 Nov;95:204-9. doi: 10.1016/j.nbd.2016.07.025. Epub 2016 Jul 28.
Neurobiol Dis. 2016.
PMID: 27477054
Free PMC article.
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