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Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40.
Alzheimers Res Ther. 2020 Jul 6;12(1):80. doi: 10.1186/s13195-020-00649-8.
Alzheimers Res Ther. 2020.
PMID: 32631408
Free PMC article.
Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease.
Suire CN, Leissring MA.
Suire CN, et al.
J Exp Neurol. 2021;2(1):10-15.
J Exp Neurol. 2021.
PMID: 33665647
Free PMC article.
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Development and Characterization of Quantitative, High-Throughput-Compatible Assays for Proteolytic Degradation of Glucagon.
Suire CN, Lane S, Leissring MA.
Suire CN, et al.
SLAS Discov. 2018 Dec;23(10):1060-1069. doi: 10.1177/2472555218786509. Epub 2018 Jul 11.
SLAS Discov. 2018.
PMID: 29995452
Free PMC article.
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Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis.
Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA.
Terron HM, et al.
Res Sq [Preprint]. 2023 Oct 23:rs.3.rs-3464352. doi: 10.21203/rs.3.rs-3464352/v1.
Res Sq. 2023.
PMID: 37961253
Free PMC article.
Updated.
Preprint.
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Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity.
Fernández-Díaz CM, Merino B, López-Acosta JF, Cidad P, de la Fuente MA, Lobatón CD, Moreno A, Leissring MA, Perdomo G, Cózar-Castellano I.
Fernández-Díaz CM, et al.
Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E805-E819. doi: 10.1152/ajpendo.00040.2019. Epub 2019 Sep 3.
Am J Physiol Endocrinol Metab. 2019.
PMID: 31479304
Free PMC article.
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