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Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.
Fu H, Chen Z, Josephson L, Li Z, Liang SH. Fu H, et al. J Med Chem. 2019 Jan 24;62(2):403-419. doi: 10.1021/acs.jmedchem.8b00714. Epub 2018 Aug 27. J Med Chem. 2019. PMID: 30110164 Free PMC article. Review.
Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2.
Zhang X, Zhang Y, Chen Z, Shao T, Van R, Kumata K, Deng X, Fu H, Yamasaki T, Rong J, Hu K, Hatori A, Xie L, Yu Q, Ye W, Xu H, Sheffler DJ, Cosford NDP, Shao Y, Tang P, Wang L, Zhang MR, Liang SH. Zhang X, et al. Theranostics. 2020 Sep 14;10(24):11178-11196. doi: 10.7150/thno.42587. eCollection 2020. Theranostics. 2020. PMID: 33042277 Free PMC article.
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors.
Korff M, Chaudhary A, Li Y, Zhou X, Zhao C, Rong J, Chen J, Xiao Z, Elghazawy NH, Sippl W, Davenport AT, Daunais JB, Wang L, Abate C, Ahmed H, Crowe R, Schmidt TJ, Liang SH, Ametamey SM, Wünsch B, Haider A. Korff M, et al. J Med Chem. 2023 Dec 14;66(23):16018-16031. doi: 10.1021/acs.jmedchem.3c01441. Epub 2023 Nov 18. J Med Chem. 2023. PMID: 37979148
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors.
Korff M, Chaudhary A, Li Y, Zhou X, Zhao C, Rong J, Chen J, Xiao Z, Elghazawy NH, Sippl W, Davenport AT, Daunais JB, Wang L, Abate C, Ahmed H, Crowe R, Liang SH, Ametamey SM, Wünsch B, Haider A. Korff M, et al. Res Sq [Preprint]. 2023 Jan 27:rs.3.rs-2516002. doi: 10.21203/rs.3.rs-2516002/v1. Res Sq. 2023. PMID: 36747738 Free PMC article. Updated. Preprint.
Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).
Yamasaki T, Zhang X, Kumata K, Zhang Y, Deng X, Fujinaga M, Chen Z, Mori W, Hu K, Wakizaka H, Hatori A, Xie L, Ogawa M, Nengaki N, Van R, Shao Y, Sheffler DJ, Cosford NDP, Liang SH, Zhang MR. Yamasaki T, et al. J Med Chem. 2020 Oct 22;63(20):11469-11483. doi: 10.1021/acs.jmedchem.9b01991. Epub 2020 Sep 22. J Med Chem. 2020. PMID: 32960052 Free PMC article.
Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.
Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH. Chen Z, et al. Eur J Med Chem. 2018 Sep 5;157:898-908. doi: 10.1016/j.ejmech.2018.08.019. Epub 2018 Aug 9. Eur J Med Chem. 2018. PMID: 30145376 Free PMC article.