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Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support.
Drakos SG, Badolia R, Makaju A, Kyriakopoulos CP, Wever-Pinzon O, Tracy CM, Bakhtina A, Bia R, Parnell T, Taleb I, Ramadurai DKA, Navankasattusas S, Dranow E, Hanff TC, Tseliou E, Shankar TS, Visker J, Hamouche R, Stauder EL, Caine WT, Alharethi R, Selzman CH, Franklin S. Drakos SG, et al. Circulation. 2023 Jan 31;147(5):409-424. doi: 10.1161/CIRCULATIONAHA.121.056600. Epub 2022 Nov 30. Circulation. 2023. PMID: 36448446 Free PMC article.
The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM. Franklin S, et al. Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1234-H1247. doi: 10.1152/ajpheart.00235.2016. Epub 2016 Sep 23. Am J Physiol Heart Circ Physiol. 2016. PMID: 27663768 Free PMC article.
Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart.
Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S. Warren JS, et al. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7871-E7880. doi: 10.1073/pnas.1800680115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061404 Free PMC article.
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Sato M, Kadomatsu T, Miyata K, Warren JS, Tian Z, Zhu S, Horiguchi H, Makaju A, Bakhtina A, Morinaga J, Sugizaki T, Hirashima K, Yoshinobu K, Imasaka M, Araki M, Komohara Y, Wakayama T, Nakagawa S, Franklin S, Node K, Araki K, Oike Y. Sato M, et al. Nat Commun. 2021 May 5;12(1):2529. doi: 10.1038/s41467-021-22735-7. Nat Commun. 2021. PMID: 33953175 Free PMC article.