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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.
El K, Douros JD, Willard FS, Novikoff A, Sargsyan A, Perez-Tilve D, Wainscott DB, Yang B, Chen A, Wothe D, Coupland C, Tschöp MH, Finan B, D'Alessio DA, Sloop KW, Müller TD, Campbell JE. El K, et al. Nat Metab. 2023 Jun;5(6):945-954. doi: 10.1038/s42255-023-00811-0. Epub 2023 Jun 5. Nat Metab. 2023. PMID: 37277609 Free PMC article.
The role of GIP in α-cells and glucagon secretion.
El K, Campbell JE. El K, et al. Peptides. 2020 Mar;125:170213. doi: 10.1016/j.peptides.2019.170213. Epub 2019 Nov 27. Peptides. 2020. PMID: 31785304 Free PMC article. Review.
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