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The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.
Madaio MP, Czikora I, Kvirkvelia N, McMenamin M, Yue Q, Liu T, Toque HA, Sridhar S, Covington K, Alaisami R, O'Connor PM, Caldwell RW, Chen JK, Clauss M, Brands MW, Eaton DC, Romero MJ, Lucas R. Madaio MP, et al. Kidney Int. 2019 Jun;95(6):1359-1372. doi: 10.1016/j.kint.2018.12.022. Epub 2019 Mar 21. Kidney Int. 2019. PMID: 30905471 Free PMC article.
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. Czikora I, et al. Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32. doi: 10.1164/rccm.201405-0833OC. Am J Respir Crit Care Med. 2014. PMID: 25029038 Free PMC article.