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Peptide-derived ligands for the discovery of safer opioid analgesics.
Drug Discov Today. 2024 May;29(5):103950. doi: 10.1016/j.drudis.2024.103950. Epub 2024 Mar 20.
Drug Discov Today. 2024.
PMID: 38514040
Free PMC article.
Review.
NCP, a dual kappa and mu opioid receptor agonist, is a potent analgesic against inflammatory pain without reinforcing or aversive properties.
Huang P, Ho CK, Cao D, Inan S, Rawls SM, Li M, Huang B, Pagare PP, Townsend EA, Poklis JL, Halquist MS, Banks M, Zhang Y, Liu-Chen LY.
Huang P, et al.
J Pharmacol Exp Ther. 2024 Feb 26;389(1):106-17. doi: 10.1124/jpet.123.001870. Online ahead of print.
J Pharmacol Exp Ther. 2024.
PMID: 38409113
Free article.
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