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Pre-receptor regulation of the androgen receptor.
Penning TM, Jin Y, Rizner TL, Bauman DR. Penning TM, et al. Mol Cell Endocrinol. 2008 Jan 16;281(1-2):1-8. doi: 10.1016/j.mce.2007.10.008. Epub 2007 Oct 22. Mol Cell Endocrinol. 2008. PMID: 18060684 Free PMC article. Review.
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies.
Byrns MC, Steckelbroeck S, Penning TM. Byrns MC, et al. Biochem Pharmacol. 2008 Jan 15;75(2):484-93. doi: 10.1016/j.bcp.2007.09.008. Epub 2007 Sep 14. Biochem Pharmacol. 2008. PMID: 17950253 Free PMC article.