R01 AI083713/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2008	1
2009	3
2010	12
2011	17
2012	15
2013	9
2014	9
2015	6
2016	4
2017	3
2018	2
2019	1
2020	1
2024	0

1

Inflammasome Complexes: Emerging Mechanisms and Effector Functions.

Rathinam VA, Fitzgerald KA. Rathinam VA, et al. Cell. 2016 May 5;165(4):792-800. doi: 10.1016/j.cell.2016.03.046. Cell. 2016. PMID: 27153493 Free PMC article. Review.

2

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. Heneka MT, et al. Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19. Nature. 2013. PMID: 23254930 Free PMC article.

3

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. Duewell P, et al. Nature. 2010 Apr 29;464(7293):1357-61. doi: 10.1038/nature08938. Nature. 2010. PMID: 20428172 Free PMC article.

4

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.

Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. Shimada K, et al. Immunity. 2012 Mar 23;36(3):401-14. doi: 10.1016/j.immuni.2012.01.009. Epub 2012 Feb 16. Immunity. 2012. PMID: 22342844 Free PMC article.

5

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.

Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Nakahira K, et al. Nat Immunol. 2011 Mar;12(3):222-30. doi: 10.1038/ni.1980. Epub 2010 Dec 12. Nat Immunol. 2011. PMID: 21151103 Free PMC article.

6

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.

Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. Hornung V, et al. Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11. Nat Immunol. 2008. PMID: 18604214 Free PMC article.

7

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E. Orning P, et al. Science. 2018 Nov 30;362(6418):1064-1069. doi: 10.1126/science.aau2818. Epub 2018 Oct 25. Science. 2018. PMID: 30361383 Free PMC article.

8

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.

Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E. Bauernfeind FG, et al. J Immunol. 2009 Jul 15;183(2):787-91. doi: 10.4049/jimmunol.0901363. Epub 2009 Jul 1. J Immunol. 2009. PMID: 19570822 Free PMC article.

9

Inflammasomes and anti-viral immunity.

Rathinam VA, Fitzgerald KA. Rathinam VA, et al. J Clin Immunol. 2010 Sep;30(5):632-7. doi: 10.1007/s10875-010-9431-4. Epub 2010 Jul 28. J Clin Immunol. 2010. PMID: 20665097 Review.

10

Regulation of inflammasome signaling.

Rathinam VA, Vanaja SK, Fitzgerald KA. Rathinam VA, et al. Nat Immunol. 2012 Mar 19;13(4):333-42. doi: 10.1038/ni.2237. Nat Immunol. 2012. PMID: 22430786 Free PMC article. Review.

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