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Ranpirnase (OKG-0301), a Novel Ribonuclease, Demonstrates Antiviral Activity against Adenovirus in the Ad5/NZW Rabbit Ocular Replication Model.
Romanowski EG, Yates KA, Daniels EJ, Strem BM, Romanowski JE, Kowalski RP. Romanowski EG, et al. Pathogens. 2022 Dec 7;11(12):1485. doi: 10.3390/pathogens11121485. Pathogens. 2022. PMID: 36558819 Free PMC article.
A day later, topical therapy was initiated in both eyes with 0.03% OKG-0301, 0.003% OKG-0301, saline or 0.5% cidofovir. Eyes were cultured to determine HAdV5 eye titers over 2 weeks. OKG-0301 (0.03% and 0.003%) and 0.5% cidofovir decreased viral titers compared to saline. …
A day later, topical therapy was initiated in both eyes with 0.03% OKG-0301, 0.003% OKG-0301, saline or 0.5% cidofovir. Eyes were cultured t …