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Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model.
Molecules. 2021 Jun 5;26(11):3419. doi: 10.3390/molecules26113419.
Molecules. 2021.
PMID: 34198721
Free PMC article.
Ranpirnase (OKG-0301), a Novel Ribonuclease, Demonstrates Antiviral Activity against Adenovirus in the Ad5/NZW Rabbit Ocular Replication Model.
Romanowski EG, Yates KA, Daniels EJ, Strem BM, Romanowski JE, Kowalski RP.
Romanowski EG, et al.
Pathogens. 2022 Dec 7;11(12):1485. doi: 10.3390/pathogens11121485.
Pathogens. 2022.
PMID: 36558819
Free PMC article.
A day later, topical therapy was initiated in both eyes with 0.03% OKG-0301, 0.003% OKG-0301, saline or 0.5% cidofovir. Eyes were cultured to determine HAdV5 eye titers over 2 weeks. OKG-0301 (0.03% and 0.003%) and 0.5% cidofovir decreased viral titers compared to saline. …
A day later, topical therapy was initiated in both eyes with 0.03% OKG-0301, 0.003% OKG-0301, saline or 0.5% cidofovir. Eyes were cultured t …
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