MR/P007503/1/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2017	1
2018	5
2019	8
2020	3
2021	6
2022	4
2023	2
2024	0

1

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Dougan G, Dowson C, Overington J; Next Generation Antibiotic Discovery Symposium Participants. Dougan G, et al. Drug Discov Today. 2019 Feb;24(2):452-461. doi: 10.1016/j.drudis.2018.11.015. Epub 2018 Nov 23. Drug Discov Today. 2019. PMID: 30476550 Review.

2

Mechanisms of σ⁵⁴-Dependent Transcription Initiation and Regulation.

Danson AE, Jovanovic M, Buck M, Zhang X. Danson AE, et al. J Mol Biol. 2019 Sep 20;431(20):3960-3974. doi: 10.1016/j.jmb.2019.04.022. Epub 2019 Apr 25. J Mol Biol. 2019. PMID: 31029702 Free PMC article. Review.

3

The Molecular Basis of Antibiotic Action and Resistance.

Maxwell A, Dowson CG, Spencer J. Maxwell A, et al. J Mol Biol. 2019 Aug 23;431(18):3367-3369. doi: 10.1016/j.jmb.2019.06.018. Epub 2019 Jun 29. J Mol Biol. 2019. PMID: 31265828 No abstract available.

4

There is no market for new antibiotics: this allows an open approach to research and development.

Klug DM, Idiris FIM, Blaskovich MAT, von Delft F, Dowson CG, Kirchhelle C, Roberts AP, Singer AC, Todd MH. Klug DM, et al. Wellcome Open Res. 2021 Jun 11;6:146. doi: 10.12688/wellcomeopenres.16847.1. eCollection 2021. Wellcome Open Res. 2021. PMID: 34250265 Free PMC article.

5

Detection of "Hidden" Antimicrobial Drug Resistance.

Hu Q, Yu Y, Gu D, Xie L, Chen X, Xu N, Ruan JJ, Dowson C, Ruan BH. Hu Q, et al. ACS Infect Dis. 2019 Jul 12;5(7):1252-1263. doi: 10.1021/acsinfecdis.9b00132. Epub 2019 Jun 20. ACS Infect Dis. 2019. PMID: 31243989

6

Kinetic and Structural Characterization of the First B3 Metallo-β-Lactamase with an Active-Site Glutamic Acid.

Wilson LA, Knaven EG, Morris MT, Monteiro Pedroso M, Schofield CJ, Brück TB, Boden M, Waite DW, Hugenholtz P, Guddat L, Schenk G. Wilson LA, et al. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0093621. doi: 10.1128/AAC.00936-21. Epub 2021 Jul 26. Antimicrob Agents Chemother. 2021. PMID: 34310207 Free PMC article.

7

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J. Salimraj R, et al. FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23. FEBS J. 2019. PMID: 30430727 Free PMC article.

8

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Langley GW, et al. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17. Bioorg Med Chem Lett. 2019. PMID: 31171422 Free PMC article.

9

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG. Cain R, et al. J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10. J Med Chem. 2018. PMID: 29271657 Free article.

10

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2.

Lucic A, Malla TR, Calvopiña K, Tooke CL, Brem J, McDonough MA, Spencer J, Schofield CJ. Lucic A, et al. Antibiotics (Basel). 2022 Mar 16;11(3):396. doi: 10.3390/antibiotics11030396. Antibiotics (Basel). 2022. PMID: 35326858 Free PMC article.

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