K99 CA197498/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	4
2017	2
2018	1
2019	1
2021	3
2022	1
2024	0

1

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions.

Chan AKN, Chen CW. Chan AKN, et al. Front Cell Dev Biol. 2019 May 15;7:81. doi: 10.3389/fcell.2019.00081. eCollection 2019. Front Cell Dev Biol. 2019. PMID: 31157223 Free PMC article. Review.

2

3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia.

Liu Q, Chan AKN, Chang WH, Yang L, Pokharel SP, Miyashita K, Mattson N, Xu X, Li M, Lu W, Lin RJ, Wang SY, Chen CW. Liu Q, et al. Leukemia. 2022 Jan;36(1):100-110. doi: 10.1038/s41375-021-01378-z. Epub 2021 Aug 9. Leukemia. 2022. PMID: 34373586 Free PMC article.

3

High-resolution characterization of gene function using single-cell CRISPR tiling screen.

Yang L, Chan AKN, Miyashita K, Delaney CD, Wang X, Li H, Pokharel SP, Li S, Li M, Xu X, Lu W, Liu Q, Mattson N, Chen KY, Wang J, Yuan YC, Horne D, Rosen ST, Soto-Feliciano Y, Feng Z, Hoshii T, Xiao G, Müschen M, Chen J, Armstrong SA, Chen CW. Yang L, et al. Nat Commun. 2021 Jul 1;12(1):4063. doi: 10.1038/s41467-021-24324-0. Nat Commun. 2021. PMID: 34210975 Free PMC article.

4

MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.

Zhu N, Chen M, Eng R, DeJong J, Sinha AU, Rahnamay NF, Koche R, Al-Shahrour F, Minehart JC, Chen CW, Deshpande AJ, Xu H, Chu SH, Ebert BL, Roeder RG, Armstrong SA. Zhu N, et al. J Clin Invest. 2016 Mar 1;126(3):997-1011. doi: 10.1172/JCI82978. Epub 2016 Feb 15. J Clin Invest. 2016. PMID: 26878175 Free PMC article.

5

Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications.

Kumar A, Lee SJ, Liu Q, Chan AKN, Pokharel SP, Yu J, Chen CW, Swaminathan S. Kumar A, et al. STAR Protoc. 2021 Oct 21;2(4):100874. doi: 10.1016/j.xpro.2021.100874. eCollection 2021 Dec 17. STAR Protoc. 2021. PMID: 34746857 Free PMC article.

6

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Hoshii T, Cifani P, Feng Z, Huang CH, Koche R, Chen CW, Delaney CD, Lowe SW, Kentsis A, Armstrong SA. Hoshii T, et al. Cell. 2018 Feb 22;172(5):1007-1021.e17. doi: 10.1016/j.cell.2018.01.032. Cell. 2018. PMID: 29474905 Free PMC article.

7

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Kühn MW, Song E, Feng Z, Sinha A, Chen CW, Deshpande AJ, Cusan M, Farnoud N, Mupo A, Grove C, Koche R, Bradner JE, de Stanchina E, Vassiliou GS, Hoshii T, Armstrong SA. Kühn MW, et al. Cancer Discov. 2016 Oct;6(10):1166-1181. doi: 10.1158/2159-8290.CD-16-0237. Epub 2016 Aug 17. Cancer Discov. 2016. PMID: 27535106 Free PMC article.

8

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.

Wang SP, Tang Z, Chen CW, Shimada M, Koche RP, Wang LH, Nakadai T, Chramiec A, Krivtsov AV, Armstrong SA, Roeder RG. Wang SP, et al. Mol Cell. 2017 Jul 20;67(2):308-321.e6. doi: 10.1016/j.molcel.2017.06.028. Mol Cell. 2017. PMID: 28732206 Free PMC article.

9

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. Xu H, et al. Cancer Cell. 2016 Dec 12;30(6):863-878. doi: 10.1016/j.ccell.2016.10.019. Epub 2016 Nov 23. Cancer Cell. 2016. PMID: 27889185 Free PMC article.

10

Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.

Valerio DG, Xu H, Chen CW, Hoshii T, Eisold ME, Delaney C, Cusan M, Deshpande AJ, Huang CH, Lujambio A, Zheng YG, Zuber J, Pandita TK, Lowe SW, Armstrong SA. Valerio DG, et al. Cancer Res. 2017 Apr 1;77(7):1753-1762. doi: 10.1158/0008-5472.CAN-16-2374. Epub 2017 Feb 15. Cancer Res. 2017. PMID: 28202522 Free PMC article.

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