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Protein tyrosine phosphatase activity regulates endothelial cell-cell interactions, the paracellular pathway, and capillary tube stability.
Young BA, Sui X, Kiser TD, Hyun SW, Wang P, Sakarya S, Angelini DJ, Schaphorst KL, Hasday JD, Cross AS, Romer LH, Passaniti A, Goldblum SE. Young BA, et al. Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L63-75. doi: 10.1152/ajplung.00423.2002. Epub 2003 Mar 7. Am J Physiol Lung Cell Mol Physiol. 2003. PMID: 12626337 Free article.
TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia.
Angelini DJ, Hyun SW, Grigoryev DN, Garg P, Gong P, Singh IS, Passaniti A, Hasday JD, Goldblum SE. Angelini DJ, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Dec;291(6):L1232-45. doi: 10.1152/ajplung.00109.2006. Epub 2006 Aug 4. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16891393 Free article.