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Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions.
Smaldone G, Caruso D, Sandomenico A, Iaccarino E, Focà A, Ruggiero A, Ruvo M, Vitagliano L. Smaldone G, et al. Int J Mol Sci. 2021 Oct 2;22(19):10700. doi: 10.3390/ijms221910700. Int J Mol Sci. 2021. PMID: 34639041 Free PMC article.
Surprisingly, GADD45alpha and GADD45beta, when heated, form high-molecular weight species that exhibit features (ThT binding and intrinsic label-free UV/visible fluorescence) proper of amyloid-like aggregates. Cell viability studies demonstrate that they are endowed with a …
Surprisingly, GADD45alpha and GADD45beta, when heated, form high-molecular weight species that exhibit features (ThT binding and intrinsic l …
Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry.
Sivaccumar JP, Leonardi A, Iaccarino E, Corvino G, Sanguigno L, Chambery A, Russo R, Valletta M, Latino D, Capasso D, Doti N, Ruvo M, Sandomenico A. Sivaccumar JP, et al. Int J Mol Sci. 2021 Mar 20;22(6):3166. doi: 10.3390/ijms22063166. Int J Mol Sci. 2021. PMID: 33804612 Free PMC article.
BACKGROUND: Monoclonal antibodies (mAbs) against cancer biomarkers are key reagents in diagnosis and therapy. One such relevant biomarker is a preferentially expressed antigen in melanoma (PRAME) that is selectively expressed in many tumors. ...
BACKGROUND: Monoclonal antibodies (mAbs) against cancer biomarkers are key reagents in diagnosis and therapy. One such relevant bioma …