A novel method to identify Post-Aire stages of medullary thymic epithelial cell differentiation.
Ferreirinha P, Ribeiro C, Morimoto J, Landry JJM, Matsumoto M, Meireles C, White AJ, Ohigashi I, Araújo L, Benes V, Takahama Y, Anderson G, Matsumoto M, Alves NL.
Ferreirinha P, et al.
Eur J Immunol. 2021 Feb;51(2):311-318. doi: 10.1002/eji.202048764. Epub 2020 Sep 15.
Eur J Immunol. 2021.
PMID: 32845012
Free PMC article.
Strikingly, transcriptomic analysis of mTEC(A/hi) , mTEC(B/hi) , and mTEC(C/hi) sequentially mirrored the specific genetic program of Early-, Late- and Post-Aire mTECs. Corroborating their Post-Aire nature, mTEC(C/hi) downregulated the expression of tissue-restricted antig …
Strikingly, transcriptomic analysis of mTEC(A/hi) , mTEC(B/hi) , and mTEC(C/hi) sequentially mirrored the specific genetic program of …