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A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels.
Sci Signal. 2013 Aug 13;6(288):ra69. doi: 10.1126/scisignal.2004075.
Sci Signal. 2013.
PMID: 23943609
Free PMC article.
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE.
Fribourg M, et al.
Cell. 2011 Nov 23;147(5):1011-23. doi: 10.1016/j.cell.2011.09.055.
Cell. 2011.
PMID: 22118459
Free PMC article.
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