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Structural mechanism of a drug-binding process involving a large conformational change of the protein target.
Nat Commun. 2023 Apr 5;14(1):1885. doi: 10.1038/s41467-023-36956-5.
Nat Commun. 2023.
PMID: 37019905
Free PMC article.
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Lyczek A, Berger BT, Rangwala AM, Paung Y, Tom J, Philipose H, Guo J, Albanese SK, Robers MB, Knapp S, Chodera JD, Seeliger MA.
Lyczek A, et al.
Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2111451118. doi: 10.1073/pnas.2111451118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34750265
Free PMC article.
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