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Efflux-mediated antifungal drug resistance.
Cannon RD, Lamping E, Holmes AR, Niimi K, Baret PV, Keniya MV, Tanabe K, Niimi M, Goffeau A, Monk BC. Cannon RD, et al. Clin Microbiol Rev. 2009 Apr;22(2):291-321, Table of Contents. doi: 10.1128/CMR.00051-08. Clin Microbiol Rev. 2009. PMID: 19366916 Free PMC article. Review.
Fungal PDR transporters: Phylogeny, topology, motifs and function.
Lamping E, Baret PV, Holmes AR, Monk BC, Goffeau A, Cannon RD. Lamping E, et al. Fungal Genet Biol. 2010 Feb;47(2):127-42. doi: 10.1016/j.fgb.2009.10.007. Epub 2009 Oct 24. Fungal Genet Biol. 2010. PMID: 19857594 Free PMC article. Review.
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
Holmes AR, Keniya MV, Ivnitski-Steele I, Monk BC, Lamping E, Sklar LA, Cannon RD. Holmes AR, et al. Antimicrob Agents Chemother. 2012 Mar;56(3):1508-15. doi: 10.1128/AAC.05706-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203607 Free PMC article.
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