AI055588/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2003	1
2006	2
2007	3
2008	2
2009	2
2010	4
2011	3
2013	7
2014	5
2015	1
2016	3
2021	1
2024	0

1

Structure- and Ligand-Dynamics-Based Design of Novel Antibiotics Targeting Lipid A Enzymes LpxC and LpxH in Gram-Negative Bacteria.

Zhou P, Hong J. Zhou P, et al. Acc Chem Res. 2021 Apr 6;54(7):1623-1634. doi: 10.1021/acs.accounts.0c00880. Epub 2021 Mar 15. Acc Chem Res. 2021. PMID: 33720682 Free PMC article. Review.

2

Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.

Barb AW, Zhou P. Barb AW, et al. Curr Pharm Biotechnol. 2008 Feb;9(1):9-15. doi: 10.2174/138920108783497668. Curr Pharm Biotechnol. 2008. PMID: 18289052 Free PMC article. Review.

3

Drug design from the cryptic inhibitor envelope.

Lee CJ, Liang X, Wu Q, Najeeb J, Zhao J, Gopalaswamy R, Titecat M, Sebbane F, Lemaitre N, Toone EJ, Zhou P. Lee CJ, et al. Nat Commun. 2016 Feb 25;7:10638. doi: 10.1038/ncomms10638. Nat Commun. 2016. PMID: 26912110 Free PMC article.

4

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.

Titecat M, Liang X, Lee CJ, Charlet A, Hocquet D, Lambert T, Pagès JM, Courcol R, Sebbane F, Toone EJ, Zhou P, Lemaitre N. Titecat M, et al. J Antimicrob Chemother. 2016 Oct;71(10):2874-82. doi: 10.1093/jac/dkw210. Epub 2016 Jun 20. J Antimicrob Chemother. 2016. PMID: 27330072 Free PMC article.

5

Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.

Liang X, Lee CJ, Zhao J, Toone EJ, Zhou P. Liang X, et al. J Med Chem. 2013 Sep 12;56(17):6954-6966. doi: 10.1021/jm4007774. Epub 2013 Aug 21. J Med Chem. 2013. PMID: 23914798 Free PMC article.

6

Radial sampling for fast NMR: Concepts and practices over three decades.

Coggins BE, Venters RA, Zhou P. Coggins BE, et al. Prog Nucl Magn Reson Spectrosc. 2010 Nov;57(4):381-419. doi: 10.1016/j.pnmrs.2010.07.001. Epub 2010 Jul 30. Prog Nucl Magn Reson Spectrosc. 2010. PMID: 20920757 Free PMC article. Review. No abstract available.

7

A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.

Liang X, Gopalaswamy R, Navas F 3rd, Toone EJ, Zhou P. Liang X, et al. J Org Chem. 2016 May 20;81(10):4393-8. doi: 10.1021/acs.joc.6b00589. Epub 2016 May 6. J Org Chem. 2016. PMID: 27128325 Free PMC article.

8

Sparsely-sampled, high-resolution 4-D omit spectra for detection and assignment of intermolecular NOEs of protein complexes.

Wang S, Zhou P. Wang S, et al. J Biomol NMR. 2014 Jun;59(2):51-6. doi: 10.1007/s10858-014-9834-2. Epub 2014 May 1. J Biomol NMR. 2014. PMID: 24789524 Free PMC article.

9

Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.

Zeng D, Zhao J, Chung HS, Guan Z, Raetz CR, Zhou P. Zeng D, et al. J Biol Chem. 2013 Feb 22;288(8):5475-86. doi: 10.1074/jbc.M112.447607. Epub 2013 Jan 11. J Biol Chem. 2013. PMID: 23316051 Free PMC article.

10

Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.

Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P. Coggins BE, et al. Nat Struct Biol. 2003 Aug;10(8):645-51. doi: 10.1038/nsb948. Nat Struct Biol. 2003. PMID: 12833153 Free PMC article.

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