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Genetic predisposition to mosaic Y chromosome loss in blood.
Nature. 2019 Nov;575(7784):652-657. doi: 10.1038/s41586-019-1765-3. Epub 2019 Nov 20.
Nature. 2019.
PMID: 31748747
Free PMC article.
Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men.
Forsberg LA.
Forsberg LA.
Hum Genet. 2017 May;136(5):657-663. doi: 10.1007/s00439-017-1799-2. Epub 2017 Apr 19.
Hum Genet. 2017.
PMID: 28424864
Free PMC article.
Review.
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Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99.
Mattisson J, Danielsson M, Hammond M, Davies H, Gallant CJ, Nordlund J, Raine A, Edén M, Kilander L, Ingelsson M, Dumanski JP, Halvardson J, Forsberg LA.
Mattisson J, et al.
Sci Rep. 2021 Jul 26;11(1):15160. doi: 10.1038/s41598-021-94588-5.
Sci Rep. 2021.
PMID: 34312421
Free PMC article.
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Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.
Dumanski JP, Lambert JC, Rasi C, Giedraitis V, Davies H, Grenier-Boley B, Lindgren CM, Campion D, Dufouil C; European Alzheimer’s Disease Initiative Investigators; Pasquier F, Amouyel P, Lannfelt L, Ingelsson M, Kilander L, Lind L, Forsberg LA.
Dumanski JP, et al.
Am J Hum Genet. 2016 Jun 2;98(6):1208-1219. doi: 10.1016/j.ajhg.2016.05.014. Epub 2016 May 23.
Am J Hum Genet. 2016.
PMID: 27231129
Free PMC article.
Clinical Trial.
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