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Development of Mannosylated Lipid Nanoparticles for mRNA Cancer Vaccine with High Antigen Presentation Efficiency and Immunomodulatory Capability.
Lei J, Qi S, Yu X, Gao X, Yang K, Zhang X, Cheng M, Bai B, Feng Y, Lu M, Wang Y, Li H, Yu G. Lei J, et al. Angew Chem Int Ed Engl. 2024 Mar 22;63(13):e202318515. doi: 10.1002/anie.202318515. Epub 2024 Feb 23. Angew Chem Int Ed Engl. 2024. PMID: 38320193
Insufficient accumulation of lipid nanoparticles (LNPs)-based mRNA vaccines in antigen presenting cells remains a key barrier to eliciting potent antitumor immune responses. Herein, we develop dendritic cells (DCs) targeting LNPs by taking advantage of mannose receptor-med …
Insufficient accumulation of lipid nanoparticles (LNPs)-based mRNA vaccines in antigen presenting cells remains a key barrier to elic …