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Enhancing prime editor flexibility with coiled-coil heterodimers.
Mu S, Chen H, Li Q, Gou S, Liu X, Wang J, Zheng W, Chen M, Jin Q, Lai L, Wang K, Shi H. Mu S, et al. Genome Biol. 2024 Apr 26;25(1):108. doi: 10.1186/s13059-024-03257-z. Genome Biol. 2024. PMID: 38671524 Free PMC article.
BACKGROUND: Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the large size of prime editors (PEs) hampers their delivery in vivo via …
BACKGROUND: Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double- …
ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems.
Xie J, Huang X, Wang X, Gou S, Liang Y, Chen F, Li N, Ouyang Z, Zhang Q, Ge W, Jin Q, Shi H, Zhuang Z, Zhao X, Lian M, Wang J, Ye Y, Quan L, Wu H, Wang K, Lai L. Xie J, et al. BMC Biol. 2020 Sep 23;18(1):131. doi: 10.1186/s12915-020-00866-5. BMC Biol. 2020. PMID: 32967664 Free PMC article.
RESULTS: In this study, a novel fusion adenine and cytosine base editor (ACBE) was generated by fusing a heterodimer of TadA (ecTadA(WT/*)) and an activation-induced cytidine deaminase (AID) to the N- and C-terminals of Cas9 nickase (nCas9), respectively. ...CONCLUSION: Th …
RESULTS: In this study, a novel fusion adenine and cytosine base editor (ACBE) was generated by fusing a heterodimer of TadA (ecTadA( …