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Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action.
Sci Rep. 2022 May 4;12(1):7302. doi: 10.1038/s41598-022-10776-x.
Sci Rep. 2022.
PMID: 35508636
Free PMC article.
Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics.
Ramirez-Mondragon CA, Nguyen ME, Milicaj J, Hassan BA, Tucci FJ, Muthyala R, Gao J, Taylor EA, Sham YY.
Ramirez-Mondragon CA, et al.
Int J Mol Sci. 2021 Apr 28;22(9):4619. doi: 10.3390/ijms22094619.
Int J Mol Sci. 2021.
PMID: 33924837
Free PMC article.
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