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Oxidative Stress in Cancer.
Hayes JD, Dinkova-Kostova AT, Tew KD. Hayes JD, et al. Cancer Cell. 2020 Aug 10;38(2):167-197. doi: 10.1016/j.ccell.2020.06.001. Epub 2020 Jul 9. Cancer Cell. 2020. PMID: 32649885 Free PMC article. Review.
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.
Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT. Cuadrado A, et al. Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Nat Rev Drug Discov. 2019. PMID: 30610225 Review.
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
Can Activation of NRF2 Be a Strategy against COVID-19?
Cuadrado A, Pajares M, Benito C, Jiménez-Villegas J, Escoll M, Fernández-Ginés R, Garcia Yagüe AJ, Lastra D, Manda G, Rojo AI, Dinkova-Kostova AT. Cuadrado A, et al. Trends Pharmacol Sci. 2020 Sep;41(9):598-610. doi: 10.1016/j.tips.2020.07.003. Epub 2020 Jul 14. Trends Pharmacol Sci. 2020. PMID: 32711925 Free PMC article. Review.
Regulation of the mammalian heat shock factor 1.
Dayalan Naidu S, Dinkova-Kostova AT. Dayalan Naidu S, et al. FEBS J. 2017 Jun;284(11):1606-1627. doi: 10.1111/febs.13999. Epub 2017 Feb 1. FEBS J. 2017. PMID: 28052564 Free article. Review.
The multifaceted role of Nrf2 in mitochondrial function.
Holmström KM, Kostov RV, Dinkova-Kostova AT. Holmström KM, et al. Curr Opin Toxicol. 2016 Dec;1:80-91. doi: 10.1016/j.cotox.2016.10.002. Curr Opin Toxicol. 2016. PMID: 28066829 Free PMC article. Review.
55 results