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L-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress.
Ribeiro RT, Carvalho AVS, Palavro R, Durán-Carabali LE, Zemniaçak ÂB, Amaral AU, Netto CA, Wajner M. Ribeiro RT, et al. Neurotox Res. 2023 Apr;41(2):119-140. doi: 10.1007/s12640-022-00625-0. Epub 2022 Dec 29. Neurotox Res. 2023. PMID: 36580261
Since the pathogenesis of this disorder is still poorly established, we investigated the short-lived effects of an intracerebroventricular injection of L-2-HG to neonatal rats on redox homeostasis in the cerebellum, which is mostly affected in this disorder. ...Importantly …
Since the pathogenesis of this disorder is still poorly established, we investigated the short-lived effects of an intracerebroventri …