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Dephosphorylation of the pre-initiation complex is critical for origin firing.
Mol Cell. 2023 Jan 5;83(1):12-25.e10. doi: 10.1016/j.molcel.2022.12.001. Epub 2022 Dec 20.
Mol Cell. 2023.
PMID: 36543171
Free article.
Roles of phosphatases in eukaryotic DNA replication initiation control.
Jenkinson F, Zegerman P.
Jenkinson F, et al.
DNA Repair (Amst). 2022 Oct;118:103384. doi: 10.1016/j.dnarep.2022.103384. Epub 2022 Aug 1.
DNA Repair (Amst). 2022.
PMID: 35973351
Free article.
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Global early replication disrupts gene expression and chromatin conformation in a single cell cycle.
Santos MM, Johnson MC, Fiedler L, Zegerman P.
Santos MM, et al.
Genome Biol. 2022 Oct 17;23(1):217. doi: 10.1186/s13059-022-02788-7.
Genome Biol. 2022.
PMID: 36253803
Free PMC article.
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Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans.
Gaggioli V, Kieninger MR, Klucnika A, Butler R, Zegerman P.
Gaggioli V, et al.
PLoS Genet. 2020 Dec 15;16(12):e1008948. doi: 10.1371/journal.pgen.1008948. eCollection 2020 Dec.
PLoS Genet. 2020.
PMID: 33320862
Free PMC article.
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Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase.
Johnson MC, Can G, Santos MM, Alexander D, Zegerman P.
Johnson MC, et al.
Elife. 2021 Jan 5;10:e63589. doi: 10.7554/eLife.63589.
Elife. 2021.
PMID: 33399537
Free PMC article.
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Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition.
Collart C, Smith JC, Zegerman P.
Collart C, et al.
Dev Cell. 2017 Jul 10;42(1):82-96.e3. doi: 10.1016/j.devcel.2017.06.010.
Dev Cell. 2017.
PMID: 28697335
Free PMC article.
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Checkpoint inhibition of origin firing prevents DNA topological stress.
Morafraile EC, Hänni C, Allen G, Zeisner T, Clarke C, Johnson MC, Santos MM, Carroll L, Minchell NE, Baxter J, Banks P, Lydall D, Zegerman P.
Morafraile EC, et al.
Genes Dev. 2019 Nov 1;33(21-22):1539-1554. doi: 10.1101/gad.328682.119. Epub 2019 Oct 17.
Genes Dev. 2019.
PMID: 31624083
Free PMC article.
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