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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1915 1
1922 1
1925 1
1926 1
1928 1
1929 1
1930 2
1933 1
1934 2
1935 1
1939 1
1943 1
1944 2
1947 3
1949 2
1950 2
1951 3
1952 1
1953 2
1954 4
1955 4
1956 6
1957 5
1958 7
1959 5
1960 5
1961 3
1962 9
1963 14
1964 22
1965 5
1966 19
1967 23
1968 19
1969 16
1970 23
1971 31
1972 25
1973 36
1974 52
1975 156
1976 120
1977 127
1978 167
1979 209
1980 304
1981 397
1982 446
1983 606
1984 768
1985 950
1986 1127
1987 1388
1988 1598
1989 1944
1990 2343
1991 2524
1992 2669
1993 2861
1994 3400
1995 3651
1996 3903
1997 4205
1998 4238
1999 4628
2000 5182
2001 5361
2002 5782
2003 6408
2004 7001
2005 7314
2006 7001
2007 7182
2008 7696
2009 8058
2010 8543
2011 9491
2012 9883
2013 10311
2014 10672
2015 10659
2016 8313
2017 7385
2018 9419
2019 9209
2020 9782
2021 10823
2022 10594
2023 9372
2024 3473
2025 1

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230,834 results

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Page 1
AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer.
Verdera HC, Kuranda K, Mingozzi F. Verdera HC, et al. Mol Ther. 2020 Mar 4;28(3):723-746. doi: 10.1016/j.ymthe.2019.12.010. Epub 2020 Jan 10. Mol Ther. 2020. PMID: 31972133 Free PMC article. Review.
Gene therapy with adeno-associated virus (AAV) vectors has demonstrated safety and long-term efficacy in a number of trials across target organs, including eye, liver, skeletal muscle, and the central nervous system. Since the initial evidence that AAV vectors can e …
Gene therapy with adeno-associated virus (AAV) vectors has demonstrated safety and long-term efficacy in a number of trials across ta …
Clinical use of lentiviral vectors.
Milone MC, O'Doherty U. Milone MC, et al. Leukemia. 2018 Jul;32(7):1529-1541. doi: 10.1038/s41375-018-0106-0. Epub 2018 Mar 22. Leukemia. 2018. PMID: 29654266 Free PMC article. Review.
CAR T-cell therapies engineered using lentiviral vectors have demonstrated noteworthy clinical success in patients with B-cell malignancies leading to regulatory approval of the first genetically engineered cellular therapy using lentiviral vectors. In this review, …
CAR T-cell therapies engineered using lentiviral vectors have demonstrated noteworthy clinical success in patients with B-cell malign …
Immune Responses to Viral Gene Therapy Vectors.
Shirley JL, de Jong YP, Terhorst C, Herzog RW. Shirley JL, et al. Mol Ther. 2020 Mar 4;28(3):709-722. doi: 10.1016/j.ymthe.2020.01.001. Epub 2020 Jan 10. Mol Ther. 2020. PMID: 31968213 Free PMC article. Review.
A much larger number of additional viral vectors are in various stages of clinical trials for the treatment of genetic and acquired diseases, with many more in pre-clinical testing. ...This review provides an overview of the type of immune responses that have been d …
A much larger number of additional viral vectors are in various stages of clinical trials for the treatment of genetic and acq …
Adeno-associated virus serotypes: vector toolkit for human gene therapy.
Wu Z, Asokan A, Samulski RJ. Wu Z, et al. Mol Ther. 2006 Sep;14(3):316-27. doi: 10.1016/j.ymthe.2006.05.009. Epub 2006 Jul 7. Mol Ther. 2006. PMID: 16824801 Free article. Review.
Recombinant adeno-associated viral (AAV) vectors have rapidly advanced to the forefront of gene therapy in the past decade. ...Strategies for engineering hybrid AAV vectors derived from AAV serotypes and potential implications of the rapidly expanding AAV vector …
Recombinant adeno-associated viral (AAV) vectors have rapidly advanced to the forefront of gene therapy in the past decade. ...Strate …
A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector.
Frank SB, Schulz VV, Miranti CK. Frank SB, et al. BMC Biotechnol. 2017 Feb 28;17(1):24. doi: 10.1186/s12896-017-0341-x. BMC Biotechnol. 2017. PMID: 28245848 Free PMC article.
METHODS: First, we modified the Tet-pLKO-Puro vector to make it easy ("EZ") for molecular cloning (EZ-Tet-pLKO-Puro). ...Furthermore, we provide a detailed guide for utilizing these vectors, including shRNA design strategy and simplified screening methods. ...
METHODS: First, we modified the Tet-pLKO-Puro vector to make it easy ("EZ") for molecular cloning (EZ-Tet-pLKO-Puro). ...Furthermore, …
Integrase deficient lentiviral vector: prospects for safe clinical applications.
Yew CT, Gurumoorthy N, Nordin F, Tye GJ, Wan Kamarul Zaman WS, Tan JJ, Ng MH. Yew CT, et al. PeerJ. 2022 Aug 12;10:e13704. doi: 10.7717/peerj.13704. eCollection 2022. PeerJ. 2022. PMID: 35979475 Free PMC article.
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. ...Various measures have been administered in different generations of lentiviral vector systems to r …
HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells a …
Key to Delivery: The (Epi-)genome Editing Vector Toolbox.
Just S, Büning H. Just S, et al. Methods Mol Biol. 2018;1767:147-166. doi: 10.1007/978-1-4939-7774-1_7. Methods Mol Biol. 2018. PMID: 29524133 Review.
Curing a genetic disease by repairing the underlying genetic defect is a fascinating concept that has been addressed so far by gene compensation therapy. For this, a functional copy of the gene in question together with elements controlling its expression is produce …
Curing a genetic disease by repairing the underlying genetic defect is a fascinating concept that has been addressed so far by …
S/MAR Element Facilitates Episomal Long-Term Persistence of Adeno-Associated Virus Vector Genomes in Proliferating Cells.
Hagedorn C, Schnödt-Fuchs M, Boehme P, Abdelrazik H, Lipps HJ, Büning H. Hagedorn C, et al. Hum Gene Ther. 2017 Dec;28(12):1169-1179. doi: 10.1089/hum.2017.025. Epub 2017 Jun 29. Hum Gene Ther. 2017. PMID: 28665147
To overcome this limitation and to generate AAV vectors that persist episomally in dividing cells, AAV vector genomes were equipped with a scaffold/matrix attachment region (S/MAR). After a mild antibiotic selection, cells transduced with AAV-S/MAR est …
To overcome this limitation and to generate AAV vectors that persist episomally in dividing cells, AAV vector genomes were equ …
A Hybrid Biological-Biomaterial Vector for Antigen Delivery.
Qi R, Hill A, Pfeifer BA. Qi R, et al. Methods Mol Biol. 2021;2183:461-475. doi: 10.1007/978-1-0716-0795-4_25. Methods Mol Biol. 2021. PMID: 32959260
It provides a unique and efficient mechanism to transport antigens (protein or genetic) via different mechanisms of vector design that include antigen cellular localization (cytoplasm, periplasm, cellular surface) and nonnative functionalities that assist in antigen …
It provides a unique and efficient mechanism to transport antigens (protein or genetic) via different mechanisms of vector des …
Recombinant vaccines for COVID-19.
Yadav T, Srivastava N, Mishra G, Dhama K, Kumar S, Puri B, Saxena SK. Yadav T, et al. Hum Vaccin Immunother. 2020 Dec 1;16(12):2905-2912. doi: 10.1080/21645515.2020.1820808. Epub 2020 Nov 24. Hum Vaccin Immunother. 2020. PMID: 33232211 Free PMC article. Review.
Several potential candidate vaccines being rapidly developed are in clinical evaluation. Considering the crucial role of SARS-CoV-2 spike (S) glycoprotein in virus attachment, entry, and induction of neutralizing antibodies, S protein is being widely used as a targe …
Several potential candidate vaccines being rapidly developed are in clinical evaluation. Considering the crucial role of SARS-CoV-2 spike ( …
230,834 results
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