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Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial.
Paramsothy S, Kamm MA, Kaakoush NO, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Paramsothy R, Xuan W, Lin E, Mitchell HM, Borody TJ. Paramsothy S, et al. Lancet. 2017 Mar 25;389(10075):1218-1228. doi: 10.1016/S0140-6736(17)30182-4. Epub 2017 Feb 15. Lancet. 2017. PMID: 28214091 Clinical Trial.
The primary outcome was achieved in 11 (27%) of 41 patients allocated faecal microbiota transplantation versus three (8%) of 40 who were assigned placebo (risk ratio 3.6, 95% CI 1.1-11.9; p=0.021). Adverse events were reported by 32 (78%) of 41 patients allocated faecal mi …
The primary outcome was achieved in 11 (27%) of 41 patients allocated faecal microbiota transplantation versus three (8%) of 40 who were ass …
Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis.
Paramsothy S, Nielsen S, Kamm MA, Deshpande NP, Faith JJ, Clemente JC, Paramsothy R, Walsh AJ, van den Bogaerde J, Samuel D, Leong RWL, Connor S, Ng W, Lin E, Borody TJ, Wilkins MR, Colombel JF, Mitchell HM, Kaakoush NO. Paramsothy S, et al. Gastroenterology. 2019 Apr;156(5):1440-1454.e2. doi: 10.1053/j.gastro.2018.12.001. Epub 2018 Dec 6. Gastroenterology. 2019. PMID: 30529583 Clinical Trial.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, … See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Autophagy. 2016. PMID: 26799652 Free PMC article. No abstract available.
More Flavor for Flavonoid-Based Interventions?
Kaakoush NO, Morris MJ. Kaakoush NO, et al. Trends Mol Med. 2017 Apr;23(4):293-295. doi: 10.1016/j.molmed.2017.02.008. Epub 2017 Mar 17. Trends Mol Med. 2017. PMID: 28318994
Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Paramsothy S, Paramsothy R, Rubin DT, Kamm MA, Kaakoush NO, Mitchell HM, Castaño-Rodríguez N. Paramsothy S, et al. J Crohns Colitis. 2017 Oct 1;11(10):1180-1199. doi: 10.1093/ecco-jcc/jjx063. J Crohns Colitis. 2017. PMID: 28486648 Review.
Pooled effect sizes and 95% confidence intervals were obtained using the random effects model. RESULTS: In all, 53 studies were included [41 in UC, 11 in CD, 4 in pouchitis]. ...Sub-analyses suggest remission in UC improved with increased number of FMT infusions and lower …
Pooled effect sizes and 95% confidence intervals were obtained using the random effects model. RESULTS: In all, 53 studies were inclu …
Gastroenterologist perceptions of faecal microbiota transplantation.
Paramsothy S, Walsh AJ, Borody T, Samuel D, van den Bogaerde J, Leong RW, Connor S, Ng W, Mitchell HM, Kaakoush NO, Kamm MA. Paramsothy S, et al. World J Gastroenterol. 2015 Oct 14;21(38):10907-14. doi: 10.3748/wjg.v21.i38.10907. World J Gastroenterol. 2015. PMID: 26478682 Free PMC article.
The greatest concerns regarding FMT were: 42% lack of evidence, 12% infection risk, 10% non infectious adverse effects/lack of safety data, 10% aesthetic, 10% lack of efficacy, 4% disease exacerbation, and 2% inappropriate use; 6% had no concerns. ...
The greatest concerns regarding FMT were: 42% lack of evidence, 12% infection risk, 10% non infectious adverse effects/lack of …
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome.
Fox D, Mathur A, Xue Y, Liu Y, Tan WH, Feng S, Pandey A, Ngo C, Hayward JA, Atmosukarto II, Price JD, Johnson MD, Jessberger N, Robertson AAB, Burgio G, Tscharke DC, Fox EM, Leyton DL, Kaakoush NO, Märtlbauer E, Leppla SH, Man SM. Fox D, et al. Nat Commun. 2020 Feb 6;11(1):760. doi: 10.1038/s41467-020-14534-3. Nat Commun. 2020. PMID: 32029733 Free PMC article.
Minocycline-induced microbiome alterations predict cafeteria diet-induced spatial recognition memory impairments in rats.
Leigh SJ, Kaakoush NO, Westbrook RF, Morris MJ. Leigh SJ, et al. Transl Psychiatry. 2020 Mar 13;10(1):92. doi: 10.1038/s41398-020-0774-1. Transl Psychiatry. 2020. PMID: 32170156 Free PMC article.
Further, minocycline normalized diet-induced increases in hippocampal pro-inflammatory gene expression. No effects of minocycline were seen on adiposity or dietary intake across the experiments. ...
Further, minocycline normalized diet-induced increases in hippocampal pro-inflammatory gene expression. No effects of minocycline wer …
Obesogenic Diet Cycling Produces Graded Effects on Cognition and Microbiota Composition in Rats.
Kendig MD, Leigh SJ, Hasebe K, Kaakoush NO, Westbrook RF, Morris MJ. Kendig MD, et al. Mol Nutr Food Res. 2023 Jun;67(12):e2200809. doi: 10.1002/mnfr.202200809. Epub 2023 May 5. Mol Nutr Food Res. 2023. PMID: 37083181 Free PMC article.
SCOPE: The effects of diet cycling on cognition and fecal microbiota are not well understood. ...
SCOPE: The effects of diet cycling on cognition and fecal microbiota are not well understood. ...
Irradiation-Induced Dysbiosis: The Compounding Effect of High-Fat Diet on Metabolic and Immune Functions in Mice.
Clifford BK, Amorim NML, Kaakoush NO, Boysen L, Tedla N, Goldstein D, Hardeman EC, Simar D. Clifford BK, et al. Int J Mol Sci. 2023 Mar 15;24(6):5631. doi: 10.3390/ijms24065631. Int J Mol Sci. 2023. PMID: 36982703 Free PMC article.
Mice fed a HFD also showed altered microbiota, irrespective of irradiation status. An altered diet may exacerbate the detrimental effects of irradiation on both the metabolic and inflammatory profiles. ...
Mice fed a HFD also showed altered microbiota, irrespective of irradiation status. An altered diet may exacerbate the detrimental effects …
14 results