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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1812 1
1813 4
1815 1
1817 1
1818 1
1823 2
1828 2
1829 2
1830 2
1831 2
1832 2
1833 2
1838 1
1839 1
1843 7
1845 3
1847 3
1848 1
1849 3
1850 1
1851 2
1852 4
1853 1
1854 1
1855 4
1856 9
1857 16
1858 14
1859 9
1860 10
1861 9
1862 11
1863 12
1864 11
1865 10
1866 14
1867 9
1868 3
1869 5
1871 4
1872 1
1873 4
1874 1
1875 2
1876 2
1877 3
1878 2
1879 3
1881 1
1882 2
1883 3
1884 2
1886 3
1887 5
1888 2
1890 1
1893 2
1894 3
1895 3
1896 5
1897 6
1898 7
1899 3
1900 1
1901 3
1902 4
1903 2
1904 1
1905 5
1906 3
1907 4
1908 7
1909 13
1910 9
1911 9
1912 14
1913 14
1914 8
1915 8
1916 7
1917 8
1918 5
1919 12
1920 7
1921 5
1922 9
1923 8
1924 8
1925 4
1926 9
1927 4
1928 10
1929 7
1930 9
1931 8
1932 8
1933 9
1934 12
1935 7
1936 6
1937 8
1938 11
1939 5
1940 7
1941 13
1942 8
1943 7
1944 8
1945 19
1946 26
1947 36
1948 41
1949 23
1950 67
1951 74
1952 61
1953 78
1954 85
1955 80
1956 72
1957 85
1958 85
1959 94
1960 109
1961 113
1962 116
1963 171
1964 167
1965 173
1966 254
1967 319
1968 357
1969 424
1970 510
1971 952
1972 1285
1973 1351
1974 1456
1975 3462
1976 3581
1977 3368
1978 3621
1979 3835
1980 4211
1981 4667
1982 5082
1983 5887
1984 6184
1985 6530
1986 6861
1987 6911
1988 7198
1989 8487
1990 8489
1991 8528
1992 8593
1993 8661
1994 8930
1995 8720
1996 9202
1997 9071
1998 9288
1999 9646
2000 9971
2001 10039
2002 10163
2003 10738
2004 11566
2005 12237
2006 12901
2007 13203
2008 14152
2009 14556
2010 15429
2011 16865
2012 18157
2013 18850
2014 19867
2015 20482
2016 21077
2017 21378
2018 22402
2019 23581
2020 27494
2021 30461
2022 30100
2023 27989
2024 13010
2025 1

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574,217 results

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Page 1
Relevance of Half-Life in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2018 May 24;61(10):4273-4282. doi: 10.1021/acs.jmedchem.7b00969. Epub 2017 Nov 17. J Med Chem. 2018. PMID: 29112446
Drug half-life has important implications for dosing regimen and peak-to-trough ratio at the steady state. A half-life of 12-48 h is generally ideal for once daily dosing of oral drugs. ...
Drug half-life has important implications for dosing regimen and peak-to-trough ratio at the steady state. A half-life of 12-4 …
Polychlorinated biphenyl (PCB) half-lives in humans: A systematic review.
Idowu IG, Megson D, Tiktak G, Dereviankin M, Sandau CD. Idowu IG, et al. Chemosphere. 2023 Dec;345:140359. doi: 10.1016/j.chemosphere.2023.140359. Epub 2023 Oct 11. Chemosphere. 2023. PMID: 37832892 Free article. Review.
Terminology for reporting PCB half-lives was inconsistent, so we have attempted to consolidate this and recommend using either "apparent half-life" or "intrinsic half-life" in future studies. Within the literature, values for reported half-lives varied …
Terminology for reporting PCB half-lives was inconsistent, so we have attempted to consolidate this and recommend using either "appar …
Estimation of Attainment of Steady-State Conditions for Compounds With a Long Half-Life.
Krause A, Lott D, Dingemanse J. Krause A, et al. J Clin Pharmacol. 2021 Jan;61(1):82-89. doi: 10.1002/jcph.1701. Epub 2020 Jul 12. J Clin Pharmacol. 2021. PMID: 32656870 Review.
Different definitions such as noncompartmental half-life, terminal half-life, effective half-life, and context-sensitive half-life can yield substantially different estimates of the quantity "half-life." Time to attainment of steady-state condit …
Different definitions such as noncompartmental half-life, terminal half-life, effective half-life, and context-sensitiv …
Eight-and-a-half syndrome caused by a pontine haemorrhage: a case report and review of the literature.
Xia NG, Chen YY, Li J, Chen X, Ye ZS, Chen SY, Zhu ZG. Xia NG, et al. Int J Neurosci. 2018 Aug;128(8):746-750. doi: 10.1080/00207454.2017.1418344. Epub 2017 Dec 29. Int J Neurosci. 2018. PMID: 29243534 Review.
It is characterized by one-and-a-half syndrome and an ipsilateral cranial nerve VII palsy. Also, many variants of eight-and-a-half syndrome have been described, including nine syndrome, thirteen-and-a-half syndrome and fifteen-and-a-half syndrome. ...I …
It is characterized by one-and-a-half syndrome and an ipsilateral cranial nerve VII palsy. Also, many variants of eight-and-a-half …
A glass of half and half.
Rosu-Finsen A. Rosu-Finsen A. Nat Rev Chem. 2023 Jun;7(6):378. doi: 10.1038/s41570-023-00508-8. Nat Rev Chem. 2023. PMID: 37237161 No abstract available.
Half and half nail, is it a marker of severe COVID-19 infection?
Aouali S, Sefraoui S, Zizi N, Dikhaye S. Aouali S, et al. Ann Med Surg (Lond). 2021 Nov;71:102963. doi: 10.1016/j.amsu.2021.102963. Epub 2021 Oct 16. Ann Med Surg (Lond). 2021. PMID: 34691452 Free PMC article.
CASE REPORT: We report 2 cases of half and half nail aspect occurring during severe COVID-19 infection, without a history of kidney disease, suggesting that 'Lindsay Nails' can be considered as a severity marker. ...As well as the acral manifestations of COVID-19, t …
CASE REPORT: We report 2 cases of half and half nail aspect occurring during severe COVID-19 infection, without a history of k …
Thirteen-and-a-half Syndrome Secondary to the Brainstem Cavernoma.
Gosal JS, Khatri D, Das KK, Gajbhiye S, Mehrotra A, Jaiswal AK, Behari S. Gosal JS, et al. Neurol India. 2022 Jan-Feb;70(1):355-358. doi: 10.4103/0028-3886.338728. Neurol India. 2022. PMID: 35263913 Free article.
BACKGROUND: "Thirteen-and-a-half" is a newly described clinical syndrome characterized by the combination of the one-and-a-half syndrome with fifth and seventh cranial nerve nuclei involvement (1(1/2) + 5 + 7 = 13(1/2)). ...Interestingly, his one-and-a-half s …
BACKGROUND: "Thirteen-and-a-half" is a newly described clinical syndrome characterized by the combination of the one-and-a-half …
Biodegradation half-lives of biodiesel fuels in aquatic and terrestrial systems: A review.
Wilms W, Homa J, Woźniak-Karczewska M, Owsianiak M, Chrzanowski Ł. Wilms W, et al. Chemosphere. 2023 Feb;313:137236. doi: 10.1016/j.chemosphere.2022.137236. Epub 2022 Nov 17. Chemosphere. 2023. PMID: 36403813 Free article. Review.
The analysis focused on the variability in half-lives across fuels and experimental conditions, reporting sets of averaged half-life values and their statistical uncertainty. Across all data points, biodegradation half-lives ranged from 9 to 62 days, and were …
The analysis focused on the variability in half-lives across fuels and experimental conditions, reporting sets of averaged half …
Albumin as a versatile platform for drug half-life extension.
Sleep D, Cameron J, Evans LR. Sleep D, et al. Biochim Biophys Acta. 2013 Dec;1830(12):5526-34. doi: 10.1016/j.bbagen.2013.04.023. Epub 2013 Apr 29. Biochim Biophys Acta. 2013. PMID: 23639804 Review.
Albumin can be used in a variety of ways to increase the circulatory half-life of such molecules. SCOPE OF REVIEW: This article will review the mechanisms which underpin albumin's extraordinarily long circulatory half-life and how the understanding of these processe …
Albumin can be used in a variety of ways to increase the circulatory half-life of such molecules. SCOPE OF REVIEW: This article will …
Laparoscopic Surgery: A Systematic Review of Loop and Knot Security, Varying with the Suture and Sequences, Throws, Rotation and Destabilization of Half-Knots or Half-Hitches.
Koninckx PR, Ussia A, Wattiez A, Kondo W, Romeo A. Koninckx PR, et al. J Clin Med. 2023 Sep 24;12(19):6166. doi: 10.3390/jcm12196166. J Clin Med. 2023. PMID: 37834810 Free PMC article. Review.
Surgical knots are sequences of half-knots (H) or half-hitches (S), defined by their number of throws, by an opposite or similar rotation compared with the previous one, and for half-hitches whether they are sliding (s) or blocking (b). ...Loop security is th …
Surgical knots are sequences of half-knots (H) or half-hitches (S), defined by their number of throws, by an opposite or simil …
574,217 results
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