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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1949 1
1951 2
1955 1
1957 1
1959 3
1960 1
1961 1
1962 6
1963 7
1964 3
1965 12
1966 15
1967 12
1968 14
1969 14
1970 25
1971 29
1972 31
1973 26
1974 33
1975 77
1976 118
1977 85
1978 74
1979 93
1980 121
1981 148
1982 186
1983 171
1984 226
1985 210
1986 271
1987 251
1988 277
1989 272
1990 320
1991 330
1992 367
1993 338
1994 381
1995 418
1996 479
1997 464
1998 491
1999 550
2000 609
2001 596
2002 565
2003 553
2004 584
2005 628
2006 665
2007 623
2008 669
2009 601
2010 696
2011 699
2012 765
2013 788
2014 852
2015 948
2016 948
2017 976
2018 953
2019 1117
2020 1397
2021 1508
2022 1455
2023 1420
2024 682

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25,851 results

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Page 1
Construction of cell factory capable of efficiently converting L-tryptophan into 5-hydroxytryptamine.
Wang Y, Chen X, Chen Q, Zhou N, Wang X, Zhang A, Chen K, Ouyang P. Wang Y, et al. Microb Cell Fact. 2022 Mar 24;21(1):47. doi: 10.1186/s12934-022-01745-0. Microb Cell Fact. 2022. PMID: 35331215 Free PMC article.
BACKGROUND: L-Tryptophan (L-Trp) derivatives such as 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT), N-Acetyl-5-hydroxytryptamine and melatonin are important molecules with pharmaceutical interest. ...CONCLUSIONS: This protocol provided an efficient one- …
BACKGROUND: L-Tryptophan (L-Trp) derivatives such as 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT), N-Acetyl-5-hy …
Industrial production of L-ascorbic Acid (vitamin C) and D-isoascorbic acid.
Pappenberger G, Hohmann HP. Pappenberger G, et al. Adv Biochem Eng Biotechnol. 2014;143:143-88. doi: 10.1007/10_2013_243. Adv Biochem Eng Biotechnol. 2014. PMID: 24258144 Review.
L-ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as the long-sought antiscorbutic factor. ...Until recently, the Reichstein-Grussner process, designed in 1933, was the main industrial route. Here, D-sorbitol is converted to L …
L-ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as the long-sought antiscorbutic factor. ...Until …
4-[(18)F]Fluoro-2-D-methyl-3-mercaptopropanoyl-L-proline.
Chopra A. Chopra A. 2007 Mar 8 [updated 2008 Jan 2]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2007 Mar 8 [updated 2008 Jan 2]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641324 Free Books & Documents. Review.
Renin is an enzyme produced in the kidneys and it cleaves circulating angiotensinogen (a protein produced in the liver) to yield angiotensin I, an inactive decapeptide. The angiotensin-converting enzyme (ACE), found primarily in the lung, converts angiotensin I to a …
Renin is an enzyme produced in the kidneys and it cleaves circulating angiotensinogen (a protein produced in the liver) to yield angiotensin …
Glycine homeostasis requires reverse SHMT flux.
McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. McBride MJ, et al. Cell Metab. 2024 Jan 2;36(1):103-115.e4. doi: 10.1016/j.cmet.2023.12.001. Cell Metab. 2024. PMID: 38171330
The folate-dependent enzyme serine hydroxymethyltransferase (SHMT) reversibly converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. ...Pharmacological inhibition of whole-body SHMT1/2 and genetic knockout of liver SHMT2 elevated circulating glycine lev …
The folate-dependent enzyme serine hydroxymethyltransferase (SHMT) reversibly converts serine into glycine and a tetrahydrofolate-bou …
Review of Angiotensin-converting Enzyme Inhibitory Assay: Rapid Method in Drug Discovery of Herbal Plants.
Ahmad I, Yanuar A, Mulia K, Mun'im A. Ahmad I, et al. Pharmacogn Rev. 2017 Jan-Jun;11(21):1-7. doi: 10.4103/phrev.phrev_45_16. Pharmacogn Rev. 2017. PMID: 28503045 Free PMC article. Review.
It converts angiotensin-I to angiotensin-II. The discovery history of the ACE inhibitory activity assay method has been through a long stage for decades and development continues until today. ...Some of in vitro assay methods were used to examine the activity of ACE inhibi …
It converts angiotensin-I to angiotensin-II. The discovery history of the ACE inhibitory activity assay method has been through a lon …
L-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti.
Chen S, White CE, diCenzo GC, Zhang Y, Stogios PJ, Savchenko A, Finan TM. Chen S, et al. J Bacteriol. 2016 Feb 1;198(7):1171-81. doi: 10.1128/JB.00961-15. J Bacteriol. 2016. PMID: 26833407 Free PMC article.
Fourteen hyp genes are induced upon growth of S. meliloti on trans-4-l-Hyp, and of those, hypMNPQ encodes an ABC-type trans-4-l-Hyp transporter and hypRE encodes an epimerase that converts trans-4-l-Hyp to cis-4-d-Hyp in the bacterial cytoplasm. ...The …
Fourteen hyp genes are induced upon growth of S. meliloti on trans-4-l-Hyp, and of those, hypMNPQ encodes an ABC-type trans-4-l …
High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades.
Corrado ML, Knaus T, Schwaneberg U, Mutti FG. Corrado ML, et al. Org Process Res Dev. 2022 Jul 15;26(7):2085-2095. doi: 10.1021/acs.oprd.1c00490. Epub 2022 Mar 28. Org Process Res Dev. 2022. PMID: 35873603 Free PMC article. Review.
For instance, after optimization, the multienzyme process could convert 507 mg of l-phenylalanine into (R)-1-phenyl-1,2-diol in an overall isolated yield of 75% and >99% ee. ...Thus, (R)-phenylethanolamine was isolated in a 92% yield and >99.9% ee starting fro …
For instance, after optimization, the multienzyme process could convert 507 mg of l-phenylalanine into (R)-1-phenyl-1,2-diol i …
Cadaverine Production From L-Lysine With Chitin-Binding Protein-Mediated Lysine Decarboxylase Immobilization.
Zhou N, Zhang A, Wei G, Yang S, Xu S, Chen K, Ouyang P. Zhou N, et al. Front Bioeng Biotechnol. 2020 Mar 3;8:103. doi: 10.3389/fbioe.2020.00103. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32195228 Free PMC article.
Lysine decarboxylase (CadA) can directly convert L-lysine to cadaverine, which is an important platform chemical that can be used to produce polyamides. ...Meanwhile, the ChBD-CadA showed high specificity toward chitin and reached 93% immobilization yield within 10 …
Lysine decarboxylase (CadA) can directly convert L-lysine to cadaverine, which is an important platform chemical that can be u …
Biotransformation of L-lysine to L-pipecolic acid catalyzed by L-lysine 6-aminotransferase and pyrroline-5-carboxylate reductase.
Fujii T, Mukaihara M, Agematu H, Tsunekawa H. Fujii T, et al. Biosci Biotechnol Biochem. 2002 Mar;66(3):622-7. doi: 10.1271/bbb.66.622. Biosci Biotechnol Biochem. 2002. PMID: 12005058 Free article.
The enzyme involved in the reduction of delta1-piperideine-6-carboxylate (P6C) to L-pipecolic acid (L-PA) has never been identified. We found that Escherichia coli JM109 transformed with the lat gene encoding L-lysine 6-aminotransferase (LAT) converted …
The enzyme involved in the reduction of delta1-piperideine-6-carboxylate (P6C) to L-pipecolic acid (L-PA) has never been ident …
Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases.
Kunvariya AD, Dave SA, Modi ZJ, Patel PK, Sagar SR. Kunvariya AD, et al. Heliyon. 2023 Apr 20;9(5):e15644. doi: 10.1016/j.heliyon.2023.e15644. eCollection 2023 May. Heliyon. 2023. PMID: 37153428 Free PMC article. Review.
Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane bound dipeptidyl peptidase enzyme). ACE2 converts angiotensinogen to the heptapeptide angiotensin-(1-7). ACE2 and its product, angiotensin-(1-7), have counteracting effects against the adver …
Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane bound dipeptidyl peptidase enzyme). ACE2 converts …
25,851 results
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