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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1966 1
1976 2
1979 1
1980 3
1981 1
1982 2
1983 3
1984 1
1986 3
1987 4
1988 2
1989 2
1990 1
1992 3
1993 1
1994 3
1995 3
1996 11
1997 11
1998 15
1999 9
2000 28
2001 34
2002 75
2003 75
2004 102
2005 91
2006 106
2007 91
2008 139
2009 143
2010 170
2011 193
2012 197
2013 198
2014 226
2015 237
2016 283
2017 329
2018 323
2019 355
2020 343
2021 310
2022 330
2023 323
2024 152

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4,629 results

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Page 1
Arene-Limited Nondirected C-H Activation of Arenes.
Wedi P, van Gemmeren M. Wedi P, et al. Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13016-13027. doi: 10.1002/anie.201804727. Epub 2018 Sep 11. Angew Chem Int Ed Engl. 2018. PMID: 29985551 Review.
The nondirected C(sp(2) )-H activation of simple arenes has advanced significantly in recent years through the discovery of new catalyst systems that are able to perform transformations with the arene as the limiting reagent. ...
The nondirected C(sp(2) )-H activation of simple arenes has advanced significantly in recent years through the discovery of ne …
Iron-catalyzed arene C-H hydroxylation.
Cheng L, Wang H, Cai H, Zhang J, Gong X, Han W. Cheng L, et al. Science. 2021 Oct;374(6563):77-81. doi: 10.1126/science.abj0731. Epub 2021 Sep 30. Science. 2021. PMID: 34591631
The sustainable, undirected, and selective catalytic hydroxylation of arenes remains an ongoing research challenge because of the relative inertness of aryl carbon-hydrogen bonds, the higher reactivity of the phenolic products leading to over-oxidized by-products, and the …
The sustainable, undirected, and selective catalytic hydroxylation of arenes remains an ongoing research challenge because of the rel …
Photoelectrocatalytic Arene C-H Amination.
Zhang L, Liardet L, Luo J, Ren D, Grätzel M, Hu X. Zhang L, et al. Nat Catal. 2019 Apr;2(4):266-373. doi: 10.1038/s41929-019-0231-9. Epub 2019 Feb 18. Nat Catal. 2019. PMID: 30984910 Free PMC article.
Here we describe a strategy to use hematite, an abundant and robust photoanode, for non-directed arene C-H amination. Under illumination the photo generated holes in hematite oxidizes electron-rich arenes to radical cations which further react with azoles to …
Here we describe a strategy to use hematite, an abundant and robust photoanode, for non-directed arene C-H amination. Under il …
Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy.
Zhang F, Spring DR. Zhang F, et al. Chem Soc Rev. 2014;43(20):6906-19. doi: 10.1039/c4cs00137k. Epub 2014 Jul 1. Chem Soc Rev. 2014. PMID: 24983866 Review.
The use of coordinating moieties as directing groups for the functionalisation of aromatic carbon-hydrogen (C-H) bonds has become an efficient strategy for the selective construction of new carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds in ar …
The use of coordinating moieties as directing groups for the functionalisation of aromatic carbon-hydrogen (C-H) bonds has become an …
Regioselective Transition-Metal-Free Arene C-H Borylations: From Directing Groups to Borylation Template Reagents.
Berionni G. Berionni G. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202210284. doi: 10.1002/anie.202210284. Epub 2022 Aug 26. Angew Chem Int Ed Engl. 2022. PMID: 36026558 Review.
The latest developments in the field of electrophilic C-H borylation reactions of arenes and heteroarenes without transition metals are briefly overviewed, with a particular emphasis on the latest advances enabling the highly regioselective C-H borylations of …
The latest developments in the field of electrophilic C-H borylation reactions of arenes and heteroarenes without transition m …
Regioselective Arene C-H Alkylation Enabled by Organic Photoredox Catalysis.
Holmberg-Douglas N, Onuska NPR, Nicewicz DA. Holmberg-Douglas N, et al. Angew Chem Int Ed Engl. 2020 May 4;59(19):7425-7429. doi: 10.1002/anie.202000684. Epub 2020 Mar 17. Angew Chem Int Ed Engl. 2020. PMID: 32068943 Free PMC article.
Expanding the toolbox of C-H functionalization reactions applicable to the late-stage modification of complex molecules is of interest in medicinal chemistry, wherein the preparation of structural variants of known pharmacophores is a key strategy for drug development. ... …
Expanding the toolbox of C-H functionalization reactions applicable to the late-stage modification of complex molecules is of interes …
Rim-Differentiated C(5)-Symmetric Tiara-Pillar[5]arenes.
Guo M, Wang X, Zhan C, Demay-Drouhard P, Li W, Du K, Olson MA, Zuilhof H, Sue AC. Guo M, et al. J Am Chem Soc. 2018 Jan 10;140(1):74-77. doi: 10.1021/jacs.7b10767. Epub 2017 Dec 29. J Am Chem Soc. 2018. PMID: 29220153 Free PMC article.
The synthesis of "rim-differentiated" C(5)-symmetric pillar[5]arenes, whose two rims are decorated with different chemical functionalities, has remained a challenging task. ...Based on this new method, a series of functionalizable tiara-pillar[5]arene derivat …
The synthesis of "rim-differentiated" C(5)-symmetric pillar[5]arenes, whose two rims are decorated with different chemical fun …
I(III)-Mediated Arene C-H Amination Using (Hetero)Aryl Nucleophiles.
Motsch BJ, Kaur JY, Wengryniuk SE. Motsch BJ, et al. Org Lett. 2023 Apr 14;25(14):2548-2553. doi: 10.1021/acs.orglett.3c00809. Epub 2023 Mar 30. Org Lett. 2023. PMID: 36995156
Herein, we report the metal-free oxidative C-H amination of arenes via a "heterocyclic group transfer" reaction from an I(III) N-HVI reagent. ...The reaction proceeds under mild conditions, and mechanistic studies indicate the intermediacy of an arene radical …
Herein, we report the metal-free oxidative C-H amination of arenes via a "heterocyclic group transfer" reaction from an I(III) …
Organophotocatalytic Arene Functionalization: C-C and C-B Bond Formation.
Lee DS, Kim CS, Iqbal N, Park GS, Son KS, Cho EJ. Lee DS, et al. Org Lett. 2019 Dec 20;21(24):9950-9953. doi: 10.1021/acs.orglett.9b03877. Epub 2019 Dec 4. Org Lett. 2019. PMID: 31799856
Organophotocatalytic C-C and C-B bond formation reactions of aryl halides have been developed in the presence of an organophotosensitizer, 3,7-di([1,1'-biphenyl]-4-yl)-10-(4-(trifluoromethyl)phenyl)-10H-phenoxazine that has highly negative reduction potential …
Organophotocatalytic C-C and C-B bond formation reactions of aryl halides have been developed in the presence of an org …
Site-Selective Electrochemical Arene C-H Amination.
Alvarez EM, Stewart G, Ullah M, Lalisse R, Gutierrez O, Malapit CA. Alvarez EM, et al. J Am Chem Soc. 2024 Feb 14;146(6):3591-3597. doi: 10.1021/jacs.3c11506. Epub 2024 Jan 31. J Am Chem Soc. 2024. PMID: 38295054
The nitrogen-radical cation-pi interaction with arenes used throughout nature leads to a charge transfer mechanism, with subsequent aromatic C-N bond formation. ...Moreover, we disclose the synthetic utility of the aryl DABCOnium salt adducts leading to the direct a …
The nitrogen-radical cation-pi interaction with arenes used throughout nature leads to a charge transfer mechanism, with subsequent a …
4,629 results