Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.
Ghashghaei M, Liu Y, Ettles J, Bombaci G, Ramkumar N, Liu Z, Escano L, Miko SS, Kim Y, Waldron JA, Do K, MacPherson K, Yuen KA, Taibi T, Yue M, Arsalan A, Jin Z, Edin G, Karsan A, Morin GB, Kuchenbauer F, Perna F, Bushell M, Vu LP.
Ghashghaei M, et al.
Nat Commun. 2024 Mar 15;15(1):2340. doi: 10.1038/s41467-024-46665-2.
Nat Commun. 2024.
PMID: 38491013
Free PMC article.
Transcriptomic and proteomic profiling uncovers c-MYC as a critical downstream target which is translationally regulated by CNOT3. Global analysis of mRNA features demonstrates that CNOT3 selectively influences expression of target genes in a codon usage dependent manner. …
Transcriptomic and proteomic profiling uncovers c-MYC as a critical downstream target which is translationally regulated by CNOT3. Global …