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Page 1
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis.
Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky DJ, Kroemer G, Liu J, Tang D, Kang R. Chen X, et al. Autophagy. 2023 Jan;19(1):54-74. doi: 10.1080/15548627.2022.2059170. Epub 2022 Apr 10. Autophagy. 2023. PMID: 35403545 Free PMC article.
These findings provide a framework for understanding how selective autophagy promotes ferroptotic cell death.Abbreviations: ANXA7: annexin A7; ARNTL: aryl hydrocarbon receptor nuclear translocator like; CCK8: cell counting kit-8; CDH2: cadherin 2; CETSAs: cellular thermal shift a …
These findings provide a framework for understanding how selective autophagy promotes ferroptotic cell death.Abbreviations: ANXA7: annexin A …
Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins.
Huang Y, Zhao H, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y, Wang J, Liu Q. Huang Y, et al. Int J Biol Sci. 2023 Apr 29;19(8):2394-2408. doi: 10.7150/ijbs.77649. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215989 Free PMC article.
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nude mouse model and skin explants of human keloid. Double immunofluorescence staining showed that Zyxin was highly expressed in fibrobl …
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nud …
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
Yan R, Ge X, Pang N, Ye H, Yuan L, Cheng B, Zhou K, Yang M, Sun Y, Zhang S, Ding Z, Luo J, Ruan C, Dai K. Yan R, et al. Cell Death Dis. 2021 Oct 16;12(11):955. doi: 10.1038/s41419-021-04246-x. Cell Death Dis. 2021. PMID: 34657146 Free PMC article.
Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in thrombopoiesis is unknown. ...Reconstitution of zyxin with VASP binding site in zyxin-deficient hematopoietic progenitor cell-derived MKs restored GPIb-IX surface …
Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in thrombopoiesis is unknown. ...Recons …
Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
Zhang S, Chong LH, Woon JYX, Chua TX, Cheruba E, Yip AK, Li HY, Chiam KH, Koh CG. Zhang S, et al. Commun Biol. 2023 Jan 18;6(1):62. doi: 10.1038/s42003-023-04421-0. Commun Biol. 2023. PMID: 36653484 Free PMC article.
Interestingly, overexpression of zyxin in mESCs suppresses Oct4 and Nanog. Using an integrative biochemical and biophysical approach, we demonstrate involvement of zyxin in regulating pluripotency through actin stress fibres and focal adhesions which are known to mo …
Interestingly, overexpression of zyxin in mESCs suppresses Oct4 and Nanog. Using an integrative biochemical and biophysical approach, …
Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis.
Yip AK, Zhang S, Chong LH, Cheruba E, Woon JYX, Chua TX, Goh CJH, Yang H, Tay CY, Koh CG, Chiam KH. Yip AK, et al. Front Cell Dev Biol. 2021 Nov 18;9:735298. doi: 10.3389/fcell.2021.735298. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34869319 Free PMC article.
Cell migration speed of zyxin knockdown fibroblasts was also independent of the underlying substrate rigidity, unlike wild type fibroblasts which migrated fastest at an intermediate substrate rigidity of 14 kPa. Wild type fibroblasts exhibited durotaxis by migrating toward …
Cell migration speed of zyxin knockdown fibroblasts was also independent of the underlying substrate rigidity, unlike wild type fibro …
Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction.
Slabodnick MM, Tintori SC, Prakash M, Zhang P, Higgins CD, Chen AH, Cupp TD, Wong T, Bowie E, Jug F, Goldstein B. Slabodnick MM, et al. PLoS Genet. 2023 Mar 28;19(3):e1010319. doi: 10.1371/journal.pgen.1010319. eCollection 2023 Mar. PLoS Genet. 2023. PMID: 36976799 Free PMC article.
We used proteomic and transcriptomic approaches to identify new players, including the candidate linkers AFD-1/afadin and ZYX-1/zyxin, as contributing to C. elegans gastrulation. We found that ZYX-1/zyxin is among a family of LIM domain proteins that have transcript …
We used proteomic and transcriptomic approaches to identify new players, including the candidate linkers AFD-1/afadin and ZYX-1/zyxin …
Upregulated Cytoskeletal Proteins Promote Pathological Angiogenesis in Moyamoya Disease.
He S, Zhang J, Liu Z, Wang Y, Hao X, Wang X, Zhou Z, Ye X, Zhao Y, Zhao Y, Wang R. He S, et al. Stroke. 2023 Dec;54(12):3153-3164. doi: 10.1161/STROKEAHA.123.044476. Epub 2023 Oct 27. Stroke. 2023. PMID: 37886851
RESULTS: Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filamin A) and ZYX (zyxin) proteins were significantly higher in MMD serum compared with those in health controls (Log(2)FC >2.9 and &gt …
RESULTS: Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filami …
Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia.
Liu Q, Shi X, Zhang Y, Huang Y, Yang K, Tang Y, Ma Y, Zhang Y, Wang J, Zhang L, Zhang Q, Liu X, Lin J, Wang J, Wu W. Liu Q, et al. Front Cell Dev Biol. 2021 Jan 11;8:582282. doi: 10.3389/fcell.2020.582282. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33505959 Free PMC article.
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting protein that is essential for cell adhesion and migration. ...
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting pr …
[The Role of Zyxin in Regulating Platelet Cytoskeleton Distribution].
Cheng B, Yan R, Zhang SQ, Yang MN, Dai KS. Cheng B, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Jun;29(3):876-880. doi: 10.19746/j.cnki.issn.1009-2137.2021.03.035. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021. PMID: 34105487 Chinese.
OBJECTIVE: To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton. METHODS: Platelets were isolated from zyxin-knockout (Zyx(-/-)) and wild type (WT) mice respectively and corresponding platelet cytoskeleton components were separa …
OBJECTIVE: To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton. METHODS: Platelets were isolat …
Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.
Wen XM, Luo T, Jiang Y, Wang LH, Luo Y, Chen Q, Yang K, Yuan Y, Luo C, Zhang X, Yan ZX, Fu WJ, Tan YH, Niu Q, Xiao JF, Chen L, Wang J, Huang JF, Cui YH, Zhang X, Wang Y, Bian XW. Wen XM, et al. Lab Invest. 2020 Jun;100(6):812-823. doi: 10.1038/s41374-019-0368-9. Epub 2020 Jan 16. Lab Invest. 2020. PMID: 31949244 Free article.
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined that an actin-interacting protein, zyxin (ZYX), may involved in GBM invasion. Our own glioma cohort as well as the cancer genome atla …
Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined …
34 results