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Page 1
Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
Yan R, Ge X, Pang N, Ye H, Yuan L, Cheng B, Zhou K, Yang M, Sun Y, Zhang S, Ding Z, Luo J, Ruan C, Dai K. Yan R, et al. Cell Death Dis. 2021 Oct 16;12(11):955. doi: 10.1038/s41419-021-04246-x. Cell Death Dis. 2021. PMID: 34657146 Free PMC article.
Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in thrombopoiesis is unknown. ...Reconstitution of zyxin with VASP binding site in zyxin-deficient hematopoietic progenitor cell-derived MKs restored GPIb-IX surface …
Zyxin is upregulated during megakaryocytic differentiation; however, the role of zyxin in thrombopoiesis is unknown. ...Recons …
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J. Han X, et al. Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639. Nat Commun. 2017. PMID: 28256511 Free PMC article.
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. ...Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reo …
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defe …
Zyxin-involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status.
Li G, Song X, Li R, Sun L, Gong X, Chen C, Yang L. Li G, et al. Cell Prolif. 2019 Jan;52(1):e12532. doi: 10.1111/cpr.12532. Epub 2018 Oct 17. Cell Prolif. 2019. PMID: 30328655 Free PMC article.
CONCLUSIONS: These results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the state of actin polymerization. In particular, the change of zyxin and F-actin parallels with the change of COL II and vinculin, respecti …
CONCLUSIONS: These results demonstrate supporting evidence that in chondrocytes the level of zyxin is closely associated with the sta …
Zyxin is involved in regulation of mechanotransduction in arteriole smooth muscle cells.
Sun Z, Huang S, Li Z, Meininger GA. Sun Z, et al. Front Physiol. 2012 Dec 20;3:472. doi: 10.3389/fphys.2012.00472. eCollection 2012. Front Physiol. 2012. PMID: 23267329 Free PMC article.
Whereas, reduction of zyxin expression by using a zyxin-shRNA construct abolished the VSMC contractile response to AFM pulling forces, even though the zyxin-silenced VSMCs displayed increased adhesion to FN in both AFM adhesion assays and cell adhesion assays …
Whereas, reduction of zyxin expression by using a zyxin-shRNA construct abolished the VSMC contractile response to AFM pulling …
Actin polymerization state regulates osteogenic differentiation in human adipose-derived stem cells.
Sun B, Qu R, Fan T, Yang Y, Jiang X, Khan AU, Zhou Z, Zhang J, Wei K, Ouyang J, Dai J. Sun B, et al. Cell Mol Biol Lett. 2021 Apr 15;26(1):15. doi: 10.1186/s11658-021-00259-8. Cell Mol Biol Lett. 2021. PMID: 33858321 Free PMC article.
The FAK, vinculin, paxillin, and talin protein expression levels were highest in the JAS (20 nM) group, while zyxin expression was highest in the JAS (50 nM) group. Western blotting showed that osteogenic differentiation in the JAS (0, 1, 5, 10, 20, and 50 nM) group was en …
The FAK, vinculin, paxillin, and talin protein expression levels were highest in the JAS (20 nM) group, while zyxin expression was hi …
Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration.
Sun N, Huiatt TW, Paulin D, Li Z, Robson RM. Sun N, et al. Exp Cell Res. 2010 Feb 1;316(3):491-505. doi: 10.1016/j.yexcr.2009.10.015. Epub 2009 Oct 21. Exp Cell Res. 2010. PMID: 19853601
The synemin binding site in human zyxin was subsequently mapped to the C-terminal three tandem LIM-domain repeats, whereas the binding site for zyxin within beta-synemin is within the C-terminal 332 amino acid region (SNbetaTII) at the end of the long tail domain. T …
The synemin binding site in human zyxin was subsequently mapped to the C-terminal three tandem LIM-domain repeats, whereas the bindin …
Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains.
Sun X, Phua DYZ, Axiotakis L Jr, Smith MA, Blankman E, Gong R, Cail RC, Espinosa de Los Reyes S, Beckerle MC, Waterman CM, Alushin GM. Sun X, et al. Dev Cell. 2020 Nov 23;55(4):468-482.e7. doi: 10.1016/j.devcel.2020.09.022. Epub 2020 Oct 14. Dev Cell. 2020. PMID: 33058779 Free PMC article.
LIM domains are protein-protein interaction modules found in cytoskeletal proteins and transcriptional regulators. Here, we identify three LIM protein families (zyxin, paxillin, and FHL) whose members preferentially localize to the actin cytoskeleton in mechanically stimul …
LIM domains are protein-protein interaction modules found in cytoskeletal proteins and transcriptional regulators. Here, we identify three L …
Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography.
Shi H, Wu X, Sun S, Wang C, Vangelatos Z, Ash-Shakoor A, Grigoropoulos CP, Mather PT, Henderson JH, Ma Z. Shi H, et al. Bioact Mater. 2021 Aug 28;10:367-377. doi: 10.1016/j.bioactmat.2021.08.028. eCollection 2022 Apr. Bioact Mater. 2021. PMID: 34901553 Free PMC article.
Using this dynamic culture system, we analyzed three proteins (paxillin, vinculin and zyxin) from different layers of the focal adhesion complex in response to dynamic extracellular topographic change. ...
Using this dynamic culture system, we analyzed three proteins (paxillin, vinculin and zyxin) from different layers of the focal adhes …
Inner Nuclear Membrane Protein, SUN1, is Required for Cytoskeletal Force Generation and Focal Adhesion Maturation.
Ueda N, Maekawa M, Matsui TS, Deguchi S, Takata T, Katahira J, Higashiyama S, Hieda M. Ueda N, et al. Front Cell Dev Biol. 2022 May 18;10:885859. doi: 10.3389/fcell.2022.885859. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35663386 Free PMC article.
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the inner nuclear membrane-spanning SUN proteins and the outer nuclear membrane-spanning nesprin proteins. ...Thus, a physical link between the nucleus and cytoskeleton through SUN1 is required for …
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the inner nuclear membrane-spanning SUN proteins and the …
14 results