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Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-beta Signaling Pathways via Integrins.
Huang Y, Zhao H, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y, Wang J, Liu Q. Huang Y, et al. Int J Biol Sci. 2023 Apr 29;19(8):2394-2408. doi: 10.7150/ijbs.77649. eCollection 2023. Int J Biol Sci. 2023. PMID: 37215989 Free PMC article.
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nude mouse model and skin explants of human keloid. Double immunofluorescence staining showed that Zyxin was highly expressed in fibrobl …
Moreover, we found Zyxin inhibition could significantly alleviate skin fibrosis using Zyxin knock-down and knock-out mice, nud …
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis.
Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky DJ, Kroemer G, Liu J, Tang D, Kang R. Chen X, et al. Autophagy. 2023 Jan;19(1):54-74. doi: 10.1080/15548627.2022.2059170. Epub 2022 Apr 10. Autophagy. 2023. PMID: 35403545 Free PMC article.
These findings provide a framework for understanding how selective autophagy promotes ferroptotic cell death.Abbreviations: ANXA7: annexin A7; ARNTL: aryl hydrocarbon receptor nuclear translocator like; CCK8: cell counting kit-8; CDH2: cadherin 2; CETSAs: cellular thermal shift a …
These findings provide a framework for understanding how selective autophagy promotes ferroptotic cell death.Abbreviations: ANXA7: annexin A …
Zyxin inhibits the epithelial-mesenchymal transition process in gastric cancer by upregulating SIRT1.
Lou J, Geng S, He W, Liu SB, Shi X, Chang Y, Han S, Qian P, Amin HM, Song YH, Li Y, Zhou J. Lou J, et al. MedComm (2020). 2023 Sep 3;4(5):e357. doi: 10.1002/mco2.357. eCollection 2023 Oct. MedComm (2020). 2023. PMID: 37667739 Free PMC article.
Overexpression of zyxin inhibited the stemness and epithelial-mesenchymal transition (EMT) processes in gastric cancer cells. Zyxin also inhibited the proliferation, migration, and invasion but increased the sensitivity of cancer cells to drugs. ...
Overexpression of zyxin inhibited the stemness and epithelial-mesenchymal transition (EMT) processes in gastric cancer cells. Zyxi …
Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway.
Cai T, Bai J, Tan P, Huang Z, Liu C, Wu Z, Cheng Y, Li T, Chen Y, Ruan J, Gao L, DU Y, Fu W. Cai T, et al. Oncol Res. 2023 Jul 21;31(5):805-817. doi: 10.32604/or.2023.029549. eCollection 2023. Oncol Res. 2023. PMID: 37547758 Free PMC article.
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues. ...
The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin (ZYX) in HCC. We foun …
Upregulated Cytoskeletal Proteins Promote Pathological Angiogenesis in Moyamoya Disease.
He S, Zhang J, Liu Z, Wang Y, Hao X, Wang X, Zhou Z, Ye X, Zhao Y, Zhao Y, Wang R. He S, et al. Stroke. 2023 Dec;54(12):3153-3164. doi: 10.1161/STROKEAHA.123.044476. Epub 2023 Oct 27. Stroke. 2023. PMID: 37886851
RESULTS: Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filamin A) and ZYX (zyxin) proteins were significantly higher in MMD serum compared with those in health controls (Log(2)FC >2.9 and &gt …
RESULTS: Proteomic analysis showed that a total of 14 726 peptides and 1555 proteins were quantified by mass spectrometry data. FLNA (filami …
The role of zyxin in signal transduction and its relationship with diseases.
Wu Z, Wu D, Zhong Q, Zou X, Liu Z, Long H, Wei J, Li X, Dai F. Wu Z, et al. Front Mol Biosci. 2024 Apr 22;11:1371549. doi: 10.3389/fmolb.2024.1371549. eCollection 2024. Front Mol Biosci. 2024. PMID: 38712343 Free PMC article. Review.
This review highlighted the pivotal role of zyxin, an essential cell focal adhesions protein, in cellular biology and various diseases. ...Moreover, in fibrotic and inflammatory conditions, zyxin can modulate cellular functions and inflammatory responses. ...
This review highlighted the pivotal role of zyxin, an essential cell focal adhesions protein, in cellular biology and various disease …
Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor.
Han J, Liu G, Profirovic J, Niu J, Voyno-Yasenetskaya T. Han J, et al. FASEB J. 2009 Dec;23(12):4193-206. doi: 10.1096/fj.09-131862. Epub 2009 Aug 18. FASEB J. 2009. PMID: 19690217 Free PMC article.
We determined that zyxin binds to the C-terminal domain of PAR-1, providing a possible mechanism of involvement of zyxin as a signal transducer in PAR-1 signaling. ...The observation that zyxin targets VASP, a partner of zyxin in regulation of actin as …
We determined that zyxin binds to the C-terminal domain of PAR-1, providing a possible mechanism of involvement of zyxin as a …
Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia.
Liu Q, Shi X, Zhang Y, Huang Y, Yang K, Tang Y, Ma Y, Zhang Y, Wang J, Zhang L, Zhang Q, Liu X, Lin J, Wang J, Wu W. Liu Q, et al. Front Cell Dev Biol. 2021 Jan 11;8:582282. doi: 10.3389/fcell.2020.582282. eCollection 2020. Front Cell Dev Biol. 2021. PMID: 33505959 Free PMC article.
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting protein that is essential for cell adhesion and migration. ...
Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting pr …
The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics.
Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Paré PD, Fredberg JJ, Smith MA. Rosner SR, et al. PLoS One. 2017 Mar 9;12(3):e0171728. doi: 10.1371/journal.pone.0171728. eCollection 2017. PLoS One. 2017. PMID: 28278518 Free PMC article.
At the level of the isolated ASM cell, zyxin facilitated recovery of contractile force. Finally, at the level of the small airway embedded with a precision cut lung slice, zyxin slowed airway dilation. ...Together, these data suggest a biophysical role for zyxin …
At the level of the isolated ASM cell, zyxin facilitated recovery of contractile force. Finally, at the level of the small airway emb …
Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation.
Chan CB, Liu X, Tang X, Fu H, Ye K. Chan CB, et al. Cell Death Differ. 2007 Sep;14(9):1688-99. doi: 10.1038/sj.cdd.4402179. Epub 2007 Jun 15. Cell Death Differ. 2007. PMID: 17572661
Nuclear zyxin promotes cardiomyocyte survival, which is mediated by nuclear-activated Akt. ...Expression of zyxin S142D, a phosphorylation mimetic mutant, diminishes acinus proteolytic cleavage and chromatin condensation; by contrast, wild-type zyxin or unpho …
Nuclear zyxin promotes cardiomyocyte survival, which is mediated by nuclear-activated Akt. ...Expression of zyxin S142D, a pho …
29 results