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Zyxin Mediates Vascular Repair via Endothelial Migration Promoted by Forskolin in Mice.
Kang X, Deng Y, Cao Y, Huo Y, Luo J. Kang X, et al. Front Physiol. 2021 Oct 8;12:741699. doi: 10.3389/fphys.2021.741699. eCollection 2021. Front Physiol. 2021. PMID: 34690814 Free PMC article.
Furthermore, endothelium-specific deletion of zyxin led to similar phenotypes. Knockdown of zyxin by shRNAs in primary human ECs significantly reduced cell migration in the wound-healing assay. ...Thus, zyxin-mediated signaling might be a potential treatment …
Furthermore, endothelium-specific deletion of zyxin led to similar phenotypes. Knockdown of zyxin by shRNAs in primary human E …
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J. Han X, et al. Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639. Nat Commun. 2017. PMID: 28256511 Free PMC article.
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. ...Our findings identify zyxin as a physiological regulator of endothelial exocytosis through reo …
Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defe …
TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis.
Yang Y, Li XM, Wang JR, Li Y, Ye WL, Wang Y, Liu YX, Deng ZY, Gan WJ, Wu H. Yang Y, et al. J Inflamm (Lond). 2022 Jan 4;19(1):1. doi: 10.1186/s12950-021-00298-0. J Inflamm (Lond). 2022. PMID: 34983535 Free PMC article.
BACKGROUND: TRIP6 is a zyxin family member that serves as an adaptor protein to regulate diverse biological processes. ...
BACKGROUND: TRIP6 is a zyxin family member that serves as an adaptor protein to regulate diverse biological processes. ...
Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor.
Li P, Wei G, Cao Y, Deng Q, Han X, Huang X, Huo Y, He Y, Chen L, Luo J. Li P, et al. Blood. 2018 Feb 8;131(6):686-698. doi: 10.1182/blood-2017-08-802140. Epub 2017 Dec 5. Blood. 2018. PMID: 29208598 Free article.
Further study showed that in resting cells, myosin IIa deficiency disrupted the peripheral localization of Rab27-positive WPBs along stress fibers; on stimulation by cAMP agonists, myosin IIa in synergy with zyxin promotes the formation of a functional actin framework, whi …
Further study showed that in resting cells, myosin IIa deficiency disrupted the peripheral localization of Rab27-positive WPBs along stress …
Defective VWF secretion due to expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis.
Cao Y, Sun Y, Deng Y, Wei G, Liu J, Jin S, Dong C, Kang X, Huo Y, Zhang J, Luo J. Cao Y, et al. Blood Adv. 2022 Aug 9;6(15):4537-4552. doi: 10.1182/bloodadvances.2022008011. Blood Adv. 2022. PMID: 35764499 Free PMC article.
Finally, we presented mechanistic findings that E1841K mutation not only interferes with S1943 phosphorylation and impairs the peripheral distribution of Rab27a-positive WPBs in Ecs under quiescent condition but also interferes with S1916 phosphorylation by disrupting the interac …
Finally, we presented mechanistic findings that E1841K mutation not only interferes with S1943 phosphorylation and impairs the peripheral di …
Ectopic expression of LIM-nebulette (LASP2) reveals roles in cell migration and spreading.
Deng XA, Norris A, Panaviene Z, Moncman CL. Deng XA, et al. Cell Motil Cytoskeleton. 2008 Oct;65(10):827-40. doi: 10.1002/cm.20304. Cell Motil Cytoskeleton. 2008. PMID: 18677772 Free PMC article.
Other than that LIM-nebulette is a focal adhesion protein and interacts with zyxin, nothing is known about its function. Given that LIM-nebulette has an identical modular organization and overlapping tissue distributions to that of LASP1, we have analyzed the role of LIM-n …
Other than that LIM-nebulette is a focal adhesion protein and interacts with zyxin, nothing is known about its function. Given that L …