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Zika virus-spread, epidemiology, genome, transmission cycle, clinical manifestation, associated challenges, vaccine and antiviral drug development.
Pielnaa P, Al-Saadawe M, Saro A, Dama MF, Zhou M, Huang Y, Huang J, Xia Z. Pielnaa P, et al. Virology. 2020 Apr;543:34-42. doi: 10.1016/j.virol.2020.01.015. Epub 2020 Feb 2. Virology. 2020. PMID: 32056845 Free article. Review.
Zika Virus (ZIKV) is a Flavivirus transmitted primarily via the bite of infected Aedes aegypti mosquitoes. Globally, 87 countries and territories have recorded autochthonous mosquito-borne transmission of ZIKV as at July 2019 and distributed across four of the six W …
Zika Virus (ZIKV) is a Flavivirus transmitted primarily via the bite of infected Aedes aegypti mosquitoes. Globally, 87 countr …
Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel.
Hao H, Wu S, Lin J, Zheng Z, Zhou Y, Zhang Y, Guo Q, Tian F, Zhao M, Chen Y, Xu X, Hou L, Wang X, Tang R. Hao H, et al. Nat Biomed Eng. 2023 Jul;7(7):928-942. doi: 10.1038/s41551-023-01014-4. Epub 2023 Mar 23. Nat Biomed Eng. 2023. PMID: 36959404
The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells …
The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcuta …
Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids.
Wu H, Huang XY, Sun MX, Wang Y, Zhou HY, Tian Y, He B, Li K, Li DY, Wu AP, Wang H, Qin CF. Wu H, et al. Nat Commun. 2023 Sep 8;14(1):5541. doi: 10.1038/s41467-023-41158-0. Nat Commun. 2023. PMID: 37684223 Free PMC article.
Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. ...Overall, our results clearly demonstrate that hTSCs represent the major target cells of ZIKV, and a reduced syncytialization may result from ZIKV infection of early d …
Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. ...Overall, our results clearly demo …
Transcriptomic reveals the ferroptosis features of host response in a mouse model of Zika virus infection.
Yan Q, Zheng W, Jiang Y, Zhou P, Lai Y, Liu C, Wu P, Zhuang H, Huang H, Li G, Zhan S, Lao Z, Liu X. Yan Q, et al. J Med Virol. 2023 Jan;95(1):e28386. doi: 10.1002/jmv.28386. J Med Virol. 2023. PMID: 36477858
Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created a global health emergency. ...CYBB, HMOX1, SALT, and SLAC40A1 were selected as potential biomarkers of ZIKV infection. Finally, we validated our results using RT-qPCR and outs …
Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created a global health emergency. ...CYBB, HMOX1, …
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Xiao J, Li W, Zheng X, Qi L, Wang H, Zhang C, Wan X, Zheng Y, Zhong R, Zhou X, Lu Y, Li Z, Qiu Y, Liu C, Zhang F, Zhang Y, Xu X, Yang Z, Chen H, Zhai Q, Wei B, Wang H. Xiao J, et al. Immunity. 2020 Jan 14;52(1):109-122.e6. doi: 10.1016/j.immuni.2019.11.015. Epub 2019 Dec 24. Immunity. 2020. PMID: 31882361 Free article.
Here, we have shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression. ...Deletion of DHCR7 and the DHCR7 inhibitors including AY9944 and the chemotherapy drug tamoxifen promoted clearance of Zika virus …
Here, we have shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression. ... …
Oncolytic Zika Virus: New Option for Glioblastoma Treatment.
Zhou C, Chen Q, Chen Y, Qin CF. Zhou C, et al. DNA Cell Biol. 2023 Jun;42(6):267-273. doi: 10.1089/dna.2022.0375. Epub 2022 Nov 9. DNA Cell Biol. 2023. PMID: 36350682 Review.
Several oncolytic viruses (OVs) have been developed and validated in clinical trials with favorable safety profiles and efficacy against GBM. Recently, Zika virus (ZIKV), a mosquito-borne flavivirus, was shown to preferentially target and kill GSCs and showed promis …
Several oncolytic viruses (OVs) have been developed and validated in clinical trials with favorable safety profiles and efficacy against GBM …
NSUN2-mediated M5c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y. Wang H, et al. Emerg Microbes Infect. 2023 Dec;12(1):2178238. doi: 10.1080/22221751.2023.2178238. Emerg Microbes Infect. 2023. PMID: 36748584 Free PMC article.
The highly m(5)C methylated cytosines in IRF3 mRNA were identified, and their mutation enhanced cellular IRF3 mRNA levels. Moreover, infection with Sendai virus (SeV), vesicular stomatitis virus (VSV), herpes simplex virus 1 (HSV-1), or Zika …
The highly m(5)C methylated cytosines in IRF3 mRNA were identified, and their mutation enhanced cellular IRF3 mRNA levels. Moreover, infe …
Aerosolized Zika virus infection in Guinea pigs.
Qiu HY, Zhang NN, Ma QQ, Li RT, Guan MY, Zhang LL, Zhou J, Zhang RR, Huang XY, Yang WH, Deng YQ, Qin CF, Zhou DS. Qiu HY, et al. Emerg Microbes Infect. 2022 Dec;11(1):2350-2358. doi: 10.1080/22221751.2022.2122577. Emerg Microbes Infect. 2022. PMID: 36069671 Free PMC article.
Zika virus (ZIKV) is primarily transmitted through mosquito bites and sexual contact, and vertical transmission of ZIKV has also been observed in humans. In addition, ZIKV infection via unknown transmission routes has been frequently reported in clinical sett …
Zika virus (ZIKV) is primarily transmitted through mosquito bites and sexual contact, and vertical transmission of ZIKV has al …
Molecular and cellular insights into Zika virus-related neuropathies.
Zhou K, Wang L, Yu D, Huang H, Ji H, Mo X. Zhou K, et al. J Neurovirol. 2017 Jun;23(3):341-346. doi: 10.1007/s13365-017-0514-3. Epub 2017 Jan 26. J Neurovirol. 2017. PMID: 28127671 Free PMC article. Review.
Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and Guillain-Barre syndrome (GBS) …
Zika virus (ZIKV), a relatively elusive Aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent wi …
Current Progress in the Development of Zika Virus Vaccines.
Zhou K, Li C, Shi W, Hu X, Nandakumar KS, Jiang S, Zhang N. Zhou K, et al. Vaccines (Basel). 2021 Sep 9;9(9):1004. doi: 10.3390/vaccines9091004. Vaccines (Basel). 2021. PMID: 34579241 Free PMC article. Review.
Zika virus (ZIKV) is an arbovirus first discovered in the Americas. ZIKV infection is insidious based on its mild clinical symptoms observed after infection. ...
Zika virus (ZIKV) is an arbovirus first discovered in the Americas. ZIKV infection is insidious based on its mild clini …
186 results