Injured liver-released miRNA-122 elicits acute pulmonary inflammation via activating alveolar macrophage TLR7 signaling pathway.
Wang Y, Liang H, Jin F, Yan X, Xu G, Hu H, Liang G, Zhan S, Hu X, Zhao Q, Liu Y, Jiang ZY, Zhang CY, Chen X, Zen K.
Wang Y, et al. Among authors: zhao q.
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6162-6171. doi: 10.1073/pnas.1814139116. Epub 2019 Mar 13.
Proc Natl Acad Sci U S A. 2019.
PMID: 30867286
Free PMC article.
Furthermore, alveolar macrophage activation by miR-122 is blocked by mutating the TLR7-binding GU-rich sequence on miR-122 or knocking out macrophage TLR7. Our findings reveal a causative role of hepatic miR-122 in liver injury-induced pulmonary dysfunction....
Furthermore, alveolar macrophage activation by miR-122 is blocked by mutating the TLR7-binding GU-rich sequence on miR-122 or knockin …