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Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-κB signaling.
Miao J, Yao H, Liu J, Huang Z, Shi C, Lu X, Jiang J, Ren R, Wang C, Pan Y, Wang T, Jin H. Miao J, et al. Biochem Pharmacol. 2023 Nov;217:115817. doi: 10.1016/j.bcp.2023.115817. Epub 2023 Sep 25. Biochem Pharmacol. 2023. PMID: 37757917
The results indicated that Cau suppressed osteoclastogenesis in a time- and dose-dependent manner in vitro. Mechanistically, Cau was identified to inhibit NF-kappaB signaling pathway via modulation of KIF11-mediated mTORC1 activity. ...
The results indicated that Cau suppressed osteoclastogenesis in a time- and dose-dependent manner in vitro. Mechanistically, Cau …
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