Abstract
Two new styrylpyrones, (6R,7R,8R)-8-methoxygoniodiol (1) and (6R,7R,8R)-8-chlorogoniodiol (2), together with seven known styrylpyrones and eight other known compounds, were isolated from the leaves and/or stems of Goniothalamus amuyon. The structures of 1 and 2 were elucidated by spectral data interpretation, and the absolute stereochemistry of styrylpyrones in the diol and triol series was confirmed by X-ray crystallographic analysis and CD spectral data. Compound 2 demonstrated significant selective cytotoxicity toward the HONE-1 cancer cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Annonaceae / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Circular Dichroism
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Molecular Conformation
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Molecular Structure
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Nasopharyngeal Neoplasms
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
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Stereoisomerism
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Taiwan
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Tumor Cells, Cultured / drug effects
Substances
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8-chlorogoniodiol
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8-methoxygoniodiol
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Antineoplastic Agents, Phytogenic
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Pyrones