Numerosol A-D, new cembranoid diterpenes from the soft coral Sinularia numerosa

Yen-Ju Tseng; Yuan-Chien Yang; Shang-Kwei Wang; Chang-Yih Duh

doi:10.3390/md12063371

Numerosol A-D, new cembranoid diterpenes from the soft coral Sinularia numerosa

Mar Drugs. 2014 Jun 3;12(6):3371-80. doi: 10.3390/md12063371.

Authors

Yen-Ju Tseng¹, Yuan-Chien Yang², Shang-Kwei Wang³, Chang-Yih Duh⁴

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pit0424@yahoo.com.tw.
² Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. m995020028@student.nsysu.edu.tw.
³ Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. skwang@cc.kmu.edu.tw.
⁴ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. yihduh@mail.nsysu.edu.tw.

Abstract

Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / metabolism*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
Humans
Leukemia P388 / drug therapy*
Leukemia P388 / pathology
Mice
Sterols / chemistry
Sterols / isolation & purification
Sterols / pharmacology
Taiwan

Substances

Antineoplastic Agents
Diterpenes
Sterols