Abstract
Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP+) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.
Keywords:
MPP+induced neurotoxicity; mimengosides J and K; triterpenoids.
MeSH terms
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1-Methyl-4-phenylpyridinium / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Autoantigens
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Buddleja / chemistry*
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Cell Survival / drug effects
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Collagen Type IV
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Fruit / chemistry
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Humans
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Molecular Structure
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Neuroblastoma
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Neurons / drug effects
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Neuroprotective Agents / chemistry*
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Neuroprotective Agents / pharmacology*
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Triterpenes / chemistry*
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Autoantigens
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Collagen Type IV
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Neuroprotective Agents
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Triterpenes
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type IV collagen alpha3 chain
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1-Methyl-4-phenylpyridinium