Pd/Cu-Catalyzed Cascade C(sp3)-H Arylation and Intramolecular C-N Coupling: A One-Pot Synthesis of 3,4-2 H-Quinolinone Skeletons

Han-Zhi Xiao; Wen-Shu Wang; Yu-Song Sun; Hao Luo; Bo-Wen Li; Xiao-Dong Wang; Wei-Li Lin; Fei-Xian Luo

doi:10.1021/acs.orglett.9b00214

Pd/Cu-Catalyzed Cascade C(sp³)-H Arylation and Intramolecular C-N Coupling: A One-Pot Synthesis of 3,4-2 H-Quinolinone Skeletons

Org Lett. 2019 Mar 15;21(6):1668-1671. doi: 10.1021/acs.orglett.9b00214. Epub 2019 Feb 25.

Authors

Han-Zhi Xiao¹, Wen-Shu Wang¹, Yu-Song Sun¹, Hao Luo¹, Bo-Wen Li¹, Xiao-Dong Wang¹, Wei-Li Lin¹, Fei-Xian Luo¹

Affiliation

¹ College of Life and Environment Science , §MUC Center on Translational Neuroscience , and ¶Experimental Center of Chemistry , Minzu University of China , Beijing 100081 , China.

PMID: 30801191
DOI: 10.1021/acs.orglett.9b00214

Abstract

In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C(sp³)-H arylation of amides and intramolecular C-N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2 H-quinolinone with good regioselectivity of C-H arylation and C-N coupling from C-I and C-X bonds from readily available starting materials.

Publication types

Research Support, Non-U.S. Gov't