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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
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1997 1
2001 2
2003 2
2004 2
2005 3
2006 4
2007 2
2008 5
2009 5
2010 2
2011 3
2012 2
2013 1
2014 4
2015 5
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2022 5
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79 results

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Page 1
Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy.
Marasco LE, Dujardin G, Sousa-Luís R, Liu YH, Stigliano JN, Nomakuchi T, Proudfoot NJ, Krainer AR, Kornblihtt AR. Marasco LE, et al. Cell. 2022 Jun 9;185(12):2057-2070.e15. doi: 10.1016/j.cell.2022.04.031. Cell. 2022. PMID: 35688133 Free PMC article.
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot compensate for the lack of SMN1. Nusinersen is an antisense oligonucleotide (ASO) that upregulates E7 in …
Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1 gene. The human paralog SMN2, whose exon 7 (E7) is p …
Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance).
Sikov WM, Berry DA, Perou CM, Singh B, Cirrincione CT, Tolaney SM, Kuzma CS, Pluard TJ, Somlo G, Port ER, Golshan M, Bellon JR, Collyar D, Hahn OM, Carey LA, Hudis CA, Winer EP. Sikov WM, et al. J Clin Oncol. 2015 Jan 1;33(1):13-21. doi: 10.1200/JCO.2014.57.0572. Epub 2014 Aug 4. J Clin Oncol. 2015. PMID: 25092775 Free PMC article. Clinical Trial.
RESULTS: Patients assigned to either carboplatin or bevacizumab were less likely to complete wP and ddAC without skipped doses, dose modification, or early discontinuation resulting from toxicity. ...
RESULTS: Patients assigned to either carboplatin or bevacizumab were less likely to complete wP and ddAC without skipped doses, dose …
Exon Skipping Is Correlated with Exon Circularization.
Kelly S, Greenman C, Cook PR, Papantonis A. Kelly S, et al. J Mol Biol. 2015 Jul 31;427(15):2414-2417. doi: 10.1016/j.jmb.2015.02.018. Epub 2015 Feb 26. J Mol Biol. 2015. PMID: 25728652
We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome....
We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regula …
Maternal and best friends' influences on meal-skipping behaviours.
Pearson N, Williams L, Crawford D, Ball K. Pearson N, et al. Br J Nutr. 2012 Sep;108(5):932-8. doi: 10.1017/S000711451100612X. Epub 2012 Jan 31. Br J Nutr. 2012. PMID: 22289518
Understanding the correlates of meal-skipping behaviours is important for the design of nutrition interventions. ...Best friend and maternal factors were differentially associated with meal-skipping behaviours. For example, boys and girls who perceived that their be …
Understanding the correlates of meal-skipping behaviours is important for the design of nutrition interventions. ...Best friend and m …
Recent advances in Duchenne muscular dystrophy.
Perkins KJ, Davies KE. Perkins KJ, et al. Degener Neurol Neuromuscul Dis. 2012 Oct 11;2:141-164. doi: 10.2147/DNND.S26637. eCollection 2012. Degener Neurol Neuromuscul Dis. 2012. PMID: 30890885 Free PMC article. Review.
In particular, RNA-based modifying approaches such as exon skipping enable expression of a shorter but functional dystrophin protein and rapid progress toward clinical application. ...
In particular, RNA-based modifying approaches such as exon skipping enable expression of a shorter but functional dystrophin protein …
The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer.
Melosky B, Wheatley-Price P, Juergens RA, Sacher A, Leighl NB, Tsao MS, Cheema P, Snow S, Liu G, Card PB, Chu Q. Melosky B, et al. Lung Cancer. 2021 Oct;160:136-151. doi: 10.1016/j.lungcan.2021.06.002. Epub 2021 Jun 5. Lung Cancer. 2021. PMID: 34353680 Review.
This rapidly evolving field has produced many new targeted treatment options and promising outcomes have led to the FDA approval of seven novel agents for use in ROS1-rearranged, BRAF V600E-mutant, NTRK-rearranged, MET exon 14 skipping-mutant or RET-rearranged advanced NSC …
This rapidly evolving field has produced many new targeted treatment options and promising outcomes have led to the FDA approval of seven no …
Comprehensive Assessment of Nutrition and Dietary Influences in Hypermobile Ehlers-Danlos Syndrome-A Cross-Sectional Study.
Topan R, Pandya S, Williams S, Ruffle JK, Zarate-Lopez N, Aziz Q, Fikree A. Topan R, et al. Am J Gastroenterol. 2024 Apr 1;119(4):727-738. doi: 10.14309/ajg.0000000000002586. Epub 2024 Jan 16. Am J Gastroenterol. 2024. PMID: 37970870

RESULTS: Of 680 participants (95% female, median age 39 years), 62.1% altered their diet in the last year and 62.3% regularly skipped meals. Altered diet was associated with the following: reflux symptoms ( P < 0.001), functional dyspepsia ( P = 0.008), reported mast ce

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RESULTS: Of 680 participants (95% female, median age 39 years), 62.1% altered their diet in the last year and 62.3% regularly skipped …
Charcot's motor brain map and 19th-century neurosurgery.
Leblanc R. Leblanc R. J Neurosurg. 2021 Apr 2;135(6):1843-1848. doi: 10.3171/2020.10.JNS202651. J Neurosurg. 2021. PMID: 33799300
When the topic is broached in its historiography, it begins with Fritch and Hitzig's report on the localization of motor function in the cortex of the dog and skips rapidly to Wilder Penfield's homunculus. In that gap are found the origins of modern neurosurgery in 3 paper …
When the topic is broached in its historiography, it begins with Fritch and Hitzig's report on the localization of motor function in the cor …
Impact of Tardive Dyskinesia on Physical, Psychological, Social, and Professional Domains of Patient Lives: A Survey of Patients in the United States.
Jain R, Ayyagari R, Goldschmidt D, Zhou M, Finkbeiner S, Leo S. Jain R, et al. J Clin Psychiatry. 2023 Apr 3;84(3):22m14694. doi: 10.4088/JCP.22m14694. J Clin Psychiatry. 2023. PMID: 37022752 Free article.
Employed patients (n = 193) indicated 29.1% absenteeism, 68.4% presenteeism, and 73.5% overall work impairment. Over one-third of patients reported skipping/reducing (48.4%) or stopping (39.3%) their antipsychotic medication and stopping visits to clinicians treating their …
Employed patients (n = 193) indicated 29.1% absenteeism, 68.4% presenteeism, and 73.5% overall work impairment. Over one-third of patients r …
RNA modulation, repair and remodeling by splice switching oligonucleotides.
Kole R, Williams T, Cohen L. Kole R, et al. Acta Biochim Pol. 2004;51(2):373-8. Acta Biochim Pol. 2004. PMID: 15218534 Free article. Review.
By preventing the use of an aberrant splice site created by a mutation and enforcing re-selection of correct splice sites the RNA is repaired. Antisense induced skipping of the exon that carries a nonsense mutation remodels the mRNA and restores the reading frame of the de …
By preventing the use of an aberrant splice site created by a mutation and enforcing re-selection of correct splice sites the RNA is repaire …
79 results